在患者接种COVID-19疫苗后,发作恶化的风险
William C Y Leung1, Ryan Wui-Hang Ho1, Anthony Ka-Long Leung1
1Division of Neurology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong SAR, China.
对于患有 (PwE) 的人来说,COVID-19疫苗接种是安全的,疫苗接种后发作没有增加. 事实上,接种疫苗导致PwE的发作频率显著降低,特别是那些患有耐药性的人.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 关于疫苗接种后发作恶化 (PVSA) 的担忧导致了患者 (PwE) 中的COVID-19疫苗接种差距显著.
- 了解PVSA的实际风险和确定预测因素对于改善这一群体的疫苗接种率至关重要.
研究的目的:
- 确定患有的成年人早期 (7天) 和延迟 (30天) 的PVSA风险.
- 在PwE中确定与PVSA相关的临床预测因素.
主要方法:
- 一项回顾性队列研究,涉及786名来自特种诊所的成年PWE.
- 收集的数据包括人口统计,特征,疫苗接种状态,以及COVID-19疫苗接种前后的发作频率.
- 统计分析确定了PVSA的预测因素,并评估了发作频率的变化.
主要成果:
- 疫苗接种后7天或30天内没有观察到发作频率的显著增加;在30天后观察到发作频率的总体显著减少 (p=0.001).
- 只有5.3%的普华永道经历了PVSA. 较高的疫苗接种前发作频率 (≥1/周) 和耐药性是PVSA的预测因素.
- 接种疫苗前3个月的发作自由与PVSA风险显著降低相关 (p<0.0005).
结论:
- 对于患者来说,COVID-19疫苗接种是安全的,并且可能对有好处,显示了发作频率的减少.
- 识别高风险个体 (那些经常发作或耐药性患者) 允许定制监测,并可能减轻疫苗犹.
- 建议在接种疫苗之前至少3个月控制发作,以最大限度地降低PVSA风险.
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