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疫苗诱导的免疫力对SARS-CoV-2的免疫-微生物签名

Lesley Umeda¹, Amada Torres², Braden P Kunihiro¹

¹Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96822, USA.

|June 27, 2024

概括

接种疫苗前的肠道微生物组和炎症,特别是高流动性组盒1 (HMGB-1) 水平,可以预测SARS-CoV-2mRNA疫苗在产生中和抗体方面的有效性.

科学领域:

免疫学免疫学免疫学
微生物组研究微生物组研究
疫苗学疫苗学疫苗学

背景情况:

个体对疫苗的反应有很大差异,影响公共卫生结果.
了解这些差异对于优化疫苗有效性和疾病控制策略至关重要.

研究的目的:

为了研究SARS-CoV-2 mRNA疫苗反应的个体间差异.
检查疫苗接种前免疫和肠道微生物群特征与疫苗接种后中和抗体水平之间的关系.

主要方法:

试点研究涉及14名成年人,收集疫苗接种前和后的血液和便样本.
在10周后,特设分组为高 (HN) 和低 (LN) 中和抗体反应者.
两变相关性分析,以评估肠道微生物群,炎症和中和能力之间的关联.

主要成果:

在肠道微生物组合和炎症的显著疫苗接种前差异区分了未来的疫苗反应者.
在LN组中,Prevotella的丰度更高,与IL-17负相关,但与HMGB-1正相关.
在疫苗接种前的HMGB-1水平和10周的中和能力之间发现了显著的反相关性.

结论:

接种疫苗前的肠道微生物特征和炎症,特别是HMGB-1,可以作为SARS-CoV-2mRNA疫苗有效性的预测生物标志物.
这些发现凸显了准肠道微生物组以增强疫苗诱导免疫力的潜力.

关键词:

在HMGB-1中,它是HMGB-1.这就是SARS-CoV-2病毒.我们的肠道微生物组.这是一种炎症炎症炎症炎症.疫苗疫苗疫苗疫苗

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