异质性复合物增加了与可纳的抗真菌活性,并导致膜破坏在Candida albicans
Ovas Ahmad Dar1,2, Athar Adil Hashmi1, Abdullah Saad Al-Bogami3
1Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
Dalton transactions (Cambridge, England : 2003)
|June 27, 2024
概括
新的金属复合物与黄素和希夫基联体显示出强大的抗真菌活性. 含有的C2复合物通过准排水,有效打击耐药的Candida albicans.
科学领域:
- 协调化学 协调化学
- 抗菌剂 抗菌剂 抗菌剂
- 药用化学 医学化学
背景情况:
- 在Candida albicans中抗真菌药物耐药性是一个日益严重的临床问题.
- 金属复合物提供了针对耐药真菌感染的新型治疗策略.
- 黄素和希夫基联体因其生物活性而闻名.
研究的目的:
- 为了合成和表征Cu (II),Co (II) 和Zn (II) 的新型异构性金属复合体,用黄素和希夫基联结体.
- 为了评估这些复合物的体外抗真菌活性对抗Candida albicans.
- 调查这些复合物的潜力,以克服流可纳耐药性.
主要方法:
- 金属复合物的合成.
- 使用UV-Vis,FT-IR,NMR,ESI-MS,TGA-DTG,元素分析,导电性和磁性易感性的表征.
- 对可纳敏感和耐药的Candida albicans菌株进行抗真菌活性测试,包括与可纳的组合研究.
主要成果:
- 复合体C2 ([Co(Cur) LCl ((H2O) ]) 对敏感和耐药的Candida albicans菌株表现出显著的抑制和候选杀菌活性.
- 复合C2与可纳具有协同作用,增强了抗真菌功效.
- 复合C2在耐药菌株中表现出剂量依赖的药物排泄的抑制,这表明细胞膜的破坏.
结论:
- 合成的复合物C2是对抗耐药Candida albicans感染的有希望的候选物.
- 复杂的C2的机制涉及向和抑制对抗性真菌菌株的关键药物排泄.
- 这些发现凸显了金属-黄素-希夫基复合物作为新型抗真菌剂的潜力.
相关概念视频
03:02Colors and Magnetism
11.6K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
11.6K
01:27Combined Effects of Drugs: Synergism
3.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.8K