肌肉衍生的microRNA与年长成年人逐步抵抗训练期间的大腿瘦身量增加相关
Samia M O'Bryan1,2, Kaleen M Lavin3, Zachary A Graham3
1UAB Center for Exercise Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|June 27, 2024
概括
研究人员在老年人中确定了微RNA (miRNAs),这些微RNA与抵抗训练的大腿肌肉质量增加相关. 这些miRNAs可以作为生物标志物来预测运动反应和指导干预措施,以最大限度地提高老年人的肌肉质量.
科学领域:
- 运动生理学和分子生物学
- 表观遗传学和衰老研究.
- 在衰老中发现生物标志物
背景情况:
- 衰老导致肌肉质量下降,老年人经常表现出阻力训练 (RT) 减少的过度缩小.
- 不调节的分子过程和运动处方可能会导致老年人肌肉增长减弱.
- 微RNAs (miRNAs) 是对运动反应的关键表观遗传调节者,并与与年龄相关的疾病有关.
研究的目的:
- 在接受RT的老年人骨肌肉和血清外体中研究microRNA配置文件.
- 为了确定与RT诱导的大腿肌肉质量 (TLM) 变化相关的特定miRNA模块.
- 探索潜在的miRNA生物标志物和治疗点,以增强肌肉质量在衰老中的积累.
主要方法:
- 不针对性miRNA测序 (miRNA-seq) 在老年人骨肌肉和血清衍生的外体细胞上.
- 阻力训练干预 (30周) 与不同强度的方案 (HHH,HLH).
- 权重基因相关性网络分析 (WGCNA) 用于识别与DXA测量的TLM变化相关的miRNA模块.
主要成果:
- 在骨肌中确定了与TLM增益相关的特定miRNA模块,独立于RT剂量.
- 没有发现任何独特的miRNA模块对不同的训练剂量具有特异性.
- 对miRNA-目标相互作用的分析表明,它们在与肌肉适应相关的生物途径中起着调节作用.
结论:
- 老年人的一组microRNA与抵抗训练诱导的大腿瘦肉质量增加相关.
- 这些已识别的microRNAs代表了新的预测生物标志物,用于在老年成人中增加瘦肉质量.
- 这些生物标志物可能有助于识别对炼干预积极反应的个体,并可能指导治疗策略.
相关概念视频
Formation of Muscle Fibers from Myoblasts
5.9K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
5.9K
Muscle Recovery and Fatigue
4.5K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.5K
Exercise and Muscle Performance
6.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
6.2K
Muscles that Move the Thigh
4.0K
The thigh's motion is primarily governed by muscles originating in the pelvic girdle and inserted into the femur. One crucial muscle, the iliopsoas, is a combination of the psoas major and the iliacus muscles, sharing a common insertion point on the lesser trochanter of the femur.
Three other significant muscles are the gluteus maximus, gluteus medius, and gluteus minimus. The gluteus maximus originates from the posterior surface of the ilium, sacrum, and coccyx, and the thoracolumbar...
Three other significant muscles are the gluteus maximus, gluteus medius, and gluteus minimus. The gluteus maximus originates from the posterior surface of the ilium, sacrum, and coccyx, and the thoracolumbar...
4.0K


