活跃分子网络发现将生活方式变量与乳腺癌联系在长岛乳腺癌研究项目中
Miao Yu1,2, Qian Li1, Georgia Dolios1
1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
Environment & health (Washington, D.C.)
|June 27, 2024
概括
这项研究使用代谢学来发现绝经后妇女的生活方式和乳腺癌风险之间的分子联系. 某些血代谢物可能充当将生活方式选择与乳腺癌发展联系起来的中间体.
科学领域:
- 代谢学 代谢学 代谢学
- 分子流行病学分子流行病学
- 癌症研究 癌症研究
背景情况:
- 健康的生活方式与降低乳腺癌风险有关.
- 了解连接生活方式和乳腺癌的分子机制至关重要.
研究的目的:
- 通过网络分析,确定将生活方式因素与乳腺癌联系起来的分子机制.
- 在绝经后的妇女中调查血代谢物,生活方式和乳腺癌状况之间的关联.
主要方法:
- 使用液体染色学高分辨率质谱法 (LC-HRMS) 进行非向的血代谢分析.
- 网络分析以确定活性分子网络 (AMN) 集群.
- 通过Lasso回归来检查代谢物,乳腺癌状态和生活方式变量之间的关联.
主要成果:
- 在197个AMN集群中确定了851种"活性"代谢物.
- 乳腺癌状况与71种"活性"代谢物有关.
- 几种代谢物将生活方式因素 (例如,肉类消费,酒精,β-胡卜素,B12,叶酸) 与乳腺癌联系起来.
结论:
- 血代谢产物可以作为生活方式和乳腺癌之间的生物中间体.
- 特定的代谢物,如DiHODE,与炎症,乳腺癌和补充剂使用 (例如β-胡卜素) 有关.
- 进一步研究炎症在将补充剂使用与乳腺癌联系中的作用是有必要的.
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