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饮食中的乙醇:对其对代谢综合征的保护作用的系统审查

Fatemeh Dehbashizadeh Torghabeh¹, Behjat Javadi¹, Amirhossein Sahebkar^2,3

¹Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of diabetes and metabolic disorders

|June 27, 2024

概括

饮食醇在预防代谢综合征 (MetS) 和相关疾病方面表现有前途. 这种化合物通过抗氧化和抗炎机制提供保护作用,支持心血管和代谢健康.

科学领域:

营养科学营养科学
药理学药理学是指药理学的学科.
生物化学生物化学

背景情况:

代谢综合征 (MetS) 是一种复杂的疾病,增加了心血管疾病,2型糖尿病和脂肪肝的风险.
饮食化合物正在探索用于预防MetS,其中醇是一种天然的烯胺,显示出潜在的保护作用.

研究的目的:

系统地审查临床前证据,以了解饮食中的乙醇对MetS的保护作用.
巩固关于anethole在缓解MetS和相关疾病方面的机制的发现.

主要方法:

在主要的科学数据库 (Web of Science,PubMed,Scopus,Google Scholar) 中进行了全面的文献搜索.
包括的研究不论出版日期,不包括评论文章,非英语论文和未发表的数据.

主要成果:

醇在保护关键 MetS 特性方面表现出有效性.
机制包括抗氧化和抗炎作用,增强胰岛素分泌,氧化应激调解和改善血管功能.
还观察到mTOR/PPARγ轴的调节和动脉重塑.

结论:

醇会影响参与MetS病变的多个分子通路.
需要进一步的体外和动物研究来阐明额外的抗MetS信号通路.
临床试验对于确定人体剂量,生物可用性和药理动力学至关重要.

关键词:

糖尿病糖尿病糖尿病饮食中的无乙醇.脱脂血症是什么意思脱脂血症是什么意思代谢综合征是代谢综合征.肥胖问题肥胖问题系统性审查系统性审查

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