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三个候选SNP显示与甲状腺刺激激素的关联在euthyroid受试者:德黑兰甲状腺研究
Azita Zadeh-Vakili1, Leila Najd-Hassan-Bonab2, Mahdi Akbarzadeh2
1Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
这项研究在伊朗人群中发现了与甲状腺刺激激素 (TSH) 水平相关的特定基因变异. 这些遗传因素有助于甲状腺功能的变化,证实了其他族群的发现.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
- 人口健康 人口健康
背景情况:
- 自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH) 水平的个体间变化受遗传因素的影响.
- 全基因组关联研究已经确定了与甲状腺功能相关的众多变体.
研究的目的:
- 调查候选遗传变异与FT4和TSH血清水平的关联,在一个euthyroid伊朗人群中.
- 通过添加基因模型探索单核酸多态 (SNP) 对甲状腺激素水平的影响.
主要方法:
- 从德黑兰甲状腺研究 (TTS) 中分析了2931名与甲状腺无关的主题.
- 基因型和统计分析,以检查选择的SNP与FT4和TSH的关联.
- 哈普洛型分析以评估与甲状腺激素水平的区域关联.
主要成果:
- 在rs4338740-C等位基因与TSH水平 (P=0.0004) 之间发现了显著的关联.
- SNPs rs4954192 (ACMSD) 和rs4445669 (CADM1) 与正常的TSH水平相关 (分别P=0.011和P=0.014).
- 两个单基类型,ACGA和AC,与无甲状腺患者的TSH水平显著相关.
结论:
- 这是伊朗人口中TSH和FT4参考值的第一个遗传关联研究.
- 这些发现表明,某些影响其他人口TSH水平的基因变异也与伊朗人有关.
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