升高的甘油三/高密度脂蛋白-胆固醇比为糖尿病前期进展的危险因素:在日本进行了一项为期5年的追溯队列研究
Masanori Shimodaira1,2, Yu Minemura1, Tomohiro Nakayama2
1Department of Internal Medicine, Takara Clinic, 2511 Kanae-nagokuma, Iida-shi, Nagano, 395-0804 Japan.
Journal of diabetes and metabolic disorders
|June 27, 2024
概括
甘油三和高密度脂蛋白胆固醇 (TG/HDL-C) 的比率是日本成年人发展为糖尿病前期的危险因素. 较高的TG/HDL-C比率表明患糖尿病前期风险增加.
科学领域:
- 代谢健康 代谢健康
- 心血管疾病风险因素 心血管疾病风险因素
- 预防糖尿病 预防糖尿病
背景情况:
- 甘油三和高密度脂蛋白胆固醇 (TG/HDL-C) 的比率被认为是胰岛素抵抗的潜在指标.
- 胰岛素抵抗是2型糖尿病和代谢综合征发展的关键因素.
研究的目的:
- 研究TG/HDL-C比率与进展为糖尿病前期的风险之间的关联.
- 评估TG/HDL-C比率作为日本人口中糖尿病前期发展的预测标记.
主要方法:
- 一项纵向回顾性研究,涉及24,604名在基线没有糖尿病或糖尿病前期的日本参与者.
- 根据基线TG/HDL-C比率四分之一,参与者被分为四组.
- 采用多变量调整的考克斯回归和接收器运行特征曲线分析.
主要成果:
- 较高的TG/HDL-C比率四分位数与男性和女性糖尿病前期进展风险增加显著相关.
- 对于TG/HDL-C比率每增加1个单位,糖尿病前期进展的风险在男性中增加了9%,在女性中增加了10%.
- 确定了用于糖尿病前期预测的最佳TG/HDL-C比率截止值,尽管辨别能力中等.
结论:
- 高高的TG/HDL-C比率是日本男性和女性糖尿病前期进展的重要危险因素.
- 虽然TG/HDL-C比率是一个有用的指标,但它在预测糖尿病前期风险方面具有有限的判别力.
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