抗氧化剂系统和甲状腺功能的性别差异,非自杀自伤的抑郁青少年
Chenyu Zhang1,2, Yalan Li1, Wo Wang1
1Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, People's Republic of China.
Neuropsychiatric disease and treatment
|June 27, 2024
概括
抑郁青少年的非自杀性自我伤害 (NSSI) 与女性的抗氧化剂水平降低和男性的甲状腺功能改变有关. 这些发现表明,在青少年男性和女性中,NSSI的生物学途径不同.
科学领域:
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 大型抑郁症 (MDD) 在青少年中很普遍.
- 非自杀性自我伤害 (NSSI) 是抑郁青少年的一个重要问题.
- 抗氧化剂和甲状腺功能等生物因素与NSSI风险之间的关系尚未完全理解.
研究的目的:
- 研究非酶性抗氧化剂和甲状腺功能标记物的血清水平与抑郁青少年NSSI风险之间的关联.
- 探索这些关联中的潜在的性别差异.
主要方法:
- 对454名患有MDD的住院青少年 (13-17岁) 的电子记录进行了回顾性分析.
- 收集人口统计和临床信息的数据,包括血清中总胆红素 (Tbil),尿酸 (UA),自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH) 的水平.
- 倾向性得分匹配用于控制NSSI和没有NSSI的组之间的年龄差异.
主要成果:
- 在研究人群中,NSSI的发病率为52.6%.
- 与没有NSSI的青少年相比,患有NSSI的青少年的Tbil (P=0.046) 和UA (P=0.015) 血清水平明显较低.
- 后勤回归显示,较低的血清UA与女性的NSSI相关 (OR=0.995),而改变的TSH水平与男性的NSSI相关 (OR=0.499).
结论:
- 导致NSSI的病理机制在青少年男性和女性之间可能有所不同.
- 女青少年的NSSI似乎更多地与抗氧化剂状况有关.
- 青少年男性的NSSI似乎与甲状腺功能更密切相关.
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