在胃镜检查中优化镇静作用:对乙胺酸/醇混合物比率的研究
Shuyi Tang1, Yuling Zheng2, Xiaoli Li2
1Department of Anesthesiology, Shunde Hospital of Southern Medical University, Foshan, China.
Frontiers in medicine
|June 27, 2024
概括
埃托米达和普罗波福的1: 1比率,与德佐辛相结合,提供稳定的血液动力学和较少的不良事件,用于胃镜镇静. 这种组合可确保为接受胃镜检查的患者提供更安全,更舒适的手术.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 普罗波福和埃托米达是常见的镇静剂,具有不同的特征.
- 没有共识,用于组合普罗波福和埃托米达的最佳比率.
- 胃镜镇静需要安全有效的麻醉剂.
研究的目的:
- 为了确定etomidate和propofol的最佳比例用于胃镜检查.
- 为了评估不同镇静剂比例的血液动力学稳定性和不良事件.
- 建立一个安全有效的静止方案,用于内镜手术.
主要方法:
- 一项前性,双盲,随机对照试验,涉及162名患者.
- 三组:单纯的普罗波 (P),埃托米达特-普罗波1:2 (EP1),以及埃托米达特-普罗波1:1 (EP2).
- 监测的平均动脉压 (MAP),心率,SpO2和不良事件.
主要成果:
- 与P和EP1组相比,EP2组 (1:1比) 在T2中显示出更高的MAP (p<0.05).
- EP2组的低血压发生率显著降低 (11.1%) 与P (50%) 和EP1 (31.5%) 相比.
- 与P和EP1组相比,EP2组的注射疼痛明显减少 (p <0.05).
结论:
- 埃托米达和普罗波福的1: 1比率,与德佐,为胃镜提供血液动力学稳定性.
- 这种组合显著降低了低血压和注射疼痛的发生率.
- 1:1 etomidate-propofol混合物是无痛胃镜的安全有效选择.
相关概念视频
Parenteral Anesthetics: Overview
117
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
117
Stages of General Anesthesia
413
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
413
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
71
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
71
Sedatives and Hypnotics Drugs: Miscellaneous Agents
167
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
167
Sedatives and Hypnotics: Overview
335
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
335
Endoscopic Procedures I: Esophagogastroduodenoscopy
92
An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
During an EGD, the endoscope can be used to:
92


