在严重的COVID-19ICU患者中,肺损伤体积和内分泌网膜应激表达之间的关联
Domitille Renard1, Mikael Verdalle-Cazes2, Perrine Leprêtre1,3
1Department of Anesthesiology and Critical Care, CHU Rouen, Rouen, France.
Frontiers in medicine
|June 27, 2024
概括
在严重的COVID-19患者中,细胞内膜网膜应激 (ERS) 与肺损伤体积 (LDV) 有关. 系统性炎症与器官衰竭相关,但不是LDV,这表明COVID-19严重程度有不同的途径.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 病理生理学 病理生理学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与内质网膜应激 (ERS) 有关.
- 在COVID-19患者中,ERS,炎症和器官损伤之间的相互作用仍然不清楚.
- 了解这些关系对于在重症监护室 (ICU) 管理严重的COVID-19病例至关重要.
研究的目的:
- 在严重的COVID-19ICU患者中调查ERS和肺损伤体积 (LDV) 之间的关联.
- 探索系统性炎症标志物与器官衰竭之间的关系.
- 为了确定ERS是否解释了该患者队列中的LDV.
主要方法:
- 一个单一中心的回顾性研究分析了严重的COVID-19ICU患者.
- 胸部计算机断层扫描 (CT) 扫描在入院后24小时内评估了LDV.
- 多变量线性回归模型确定了与血GRP78 (ERS标志物) 和IL-6 (炎症标志物) 水平相关的因素.
主要成果:
- 血GRP78水平,一个ERS标志物,与LDV显著相关 (p=0.0179和p=0.0423).
- 血IL-6水平,一种炎症标志物,与器官衰竭相关 (SOFA评分) (p<0.0001),但不是LDV (p=0.3219).
- 在GRP78和IL-6血水平之间没有发现相关性 (p=0.3106).
结论:
- 在严重的COVID-19患者中,内质网膜应激与肺损伤体积有关.
- 系统性炎症与器官衰竭有关,但与肺损伤量没有直接关系.
- 这些发现表明ERS和炎症在COVID-19严重性中具有不同的病理生理学作用.
关键词:
在 COVID-19 疫情中,急性呼吸困扰综合征是什么细胞内膜网膜的压力应激人类人类人类人类人类人类.这是一种炎症炎症炎症炎症.重症监护病房的重症监护病房是一个重症监护病房.介质蛋白-6 介质蛋白-6 是一种器官衰竭 器官衰竭是指器官的缺陷.更多相关视频
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