食道静脉直径与内镜静脉结合后早期再出血之间的相关性:基于人工智能内镜虚拟规则的多中心回顾性研究
Chuankun Cao1,2, Jing Jin1, Rui Cai2
1Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Anhui Provincial Key Laboratory of Digestive Diseases, Hefei, China.
Frontiers in medicine
|June 27, 2024
概括
食道静脉 (EV) 的直径是内镜静脉结合 (EVL) 后再出血的关键预测因素. 1.4厘米或更大的EV直径表明高风险,建议在这种情况下谨慎使用EVL.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 经过内镜性水绑定 (EVL) 后的出血是一个重大问题,通常与很难完全绑定的大食道水 (EV) 有关.
- 精确测量EV直径对于选择适合EVL的候选者和最大限度地减少再出血风险至关重要.
研究的目的:
- 开发和验证基于人工智能的内镜虚拟统治器 (EVR),用于精确测量EV直径.
- 确定EV直径作为EVL后早期再出血的预测因素.
主要方法:
- 一项多中心回顾性研究,涉及727名肝硬化患者的1,062次EVL手术.
- 根据EVL后6周内出血的情况,患者被分为早期复出血 (n=80) 和非复出血 (n=982) 组.
- 使用后勤回归和ROC分析来评估风险因素,包括EV直径.
主要成果:
- 早期再出血率为7.5%,出血后6周死亡率为16.5%.
- 多因素分析确定了Child-Pugh等级C,日本水等级F3和EV直径作为早期再出血的重要预测因素.
- 与日本水等级 (AUC=0.635) 相比,EV直径显示出更高的预测值 (AUC=0.848).
- 截止EV直径为1.35厘米,预测了早期复出,灵敏度为70.0%,特异性为89.2%.
结论:
- 食道水直径是EVL后早期再出血的更优的预测因素,而不是目前的日本水分级.
- EV直径≥1.4厘米表明早期再出血的风险很高,因此在这些患者中需要谨慎使用EVL.
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