Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neuron Structure01:30

Neuron Structure

17.9K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
17.9K
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

29.1K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
29.1K
Anatomy of the Brain: Major Regions01:20

Anatomy of the Brain: Major Regions

11.4K
The brain is the most complex organ in the human body. It consists of four main parts: the cerebrum, diencephalon, cerebellum, and brainstem.
The cerebrum is the largest section of the brain and divides into left and right hemispheres, separated by a deep fissure. The cerebral outer layer of grey matter — the cerebral cortex — comprises elevations called gyri and shallow groves called sulci. The inner portion of white matter includes long nerve fibers known as axons, which connect...
11.4K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

5.7K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
5.7K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

4.9K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
4.9K
Organization of the Brain01:30

Organization of the Brain

3.7K
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
3.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Neonatal CD19<sup>+</sup>B220<sup>lo</sup> cells sense microbiota via TLR2/4 activation driving proliferation and differentiation.

Frontiers in immunology·2026
Same author

KpFhaB/FhaC is a virulence-associated TPS system of the globally-disseminated <i>Klebsiella pneumoniae</i> ST15 high-risk clone.

Frontiers in cellular and infection microbiology·2026
Same author

Comprehensive profiling of Aβ40 and Aβ42 fibril-interacting proteins reveals PRKCG as a drug-targetable regulator of amyloidogenesis in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor.

Molecular aspects of medicine·2025
Same author

In Vitro Skin Models as Non-Animal Methods for Dermal Drug Development and Safety Assessment.

Pharmaceutics·2025
Same author

Myosin-9 is required for lysosome-mediated nonlytic reovirus egress.

PLoS pathogens·2025

相关实验视频

Updated: Apr 29, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

21.4K

人类大脑器官:细胞组成和亚细胞形态特征

Patricia Mateos-Martínez1,2,3, Raquel Coronel1, Martin Sachse4

  • 1Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Frontiers in cellular neuroscience
|June 27, 2024
PubMed
概括

人类大脑器官 (hCOs) 显示出类似大脑的发育,具有多种细胞类型和结构. 这种详细的形态分析有助于未来使用hCO模型对大脑发育和疾病的研究.

关键词:
状细胞是状细胞中的一种.人类大脑的有机体人类多能干细胞干细胞迷你的大脑是一个迷你的大脑.神经干细胞的神经干细胞神经发育的神经发育传输电子显微镜的使用超结构性表征的超结构性表征.

更多相关视频

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors
10:16

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

Published on: December 11, 2021

5.5K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.1K

相关实验视频

Last Updated: Apr 29, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

21.4K
Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors
10:16

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

Published on: December 11, 2021

5.5K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.1K

科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 干细胞研究 干细胞研究

背景情况:

  • 人类大脑器官 (hCOs) 是研究神经发育和大脑疾病的宝贵模型.
  • 深入的形态表征对于确定hCOs作为可靠的研究工具至关重要.

研究的目的:

  • 执行人类大脑器官 (hCOs) 的详细形态和细胞特征.
  • 分析45天培养的hCOs中的细胞类型和亚细胞结构.

主要方法:

  • 免疫光检测用于识别细胞类型.
  • 逆转录酶定性聚合酶链反应 (RT-qPCR) 用于基因表达分析.
  • 传输电子显微镜 (TEM) 用于超结构性检查.

主要成果:

  • hCOs表现出增殖区,反映了人类大脑的发育,具有极化细胞,紧密的结节和眼.
  • 识别未成熟和成熟的迁移神经元,星体细胞,寡细胞前体细胞和微状细胞.
  • 有机体内细胞形态的详细超结构数据.

结论:

  • 超结构性表征提供了对hCO发育和形态学的关键见解.
  • 这项研究增强了hCOs的实用性,用于研究影响细胞结构和功能的机制.
  • 研究结果支持在未来的神经发育和疾病研究中使用hCOs.