完整的血液计数的临床意义,中性细胞和淋巴细胞的比率,和单细胞和淋巴细胞的比率在孕期糖尿病中
1Obstetrical Department, Fu Yang People's Hospital Affiliated to Anhui Medical University, Anhui FuYang, China.
概括
诸如白细胞 (WBC) 计数和单细胞 (MON) 水平等炎症因素与妊娠糖尿病 (GDM) 有关. 单细胞水平显示了在早期怀孕期间识别GDM风险的最高诊断值.
科学领域:
- 产科和妇科 产科和妇科
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
- 炎症在GDM的发展中起作用.
- 全血细胞计 (CBC) 成分和炎症比率是潜在的生物标志物.
研究的目的:
- 调查炎症因素与GDM之间的关联.
- 为了评估CBC组件,中性粒细胞/淋巴细胞比率 (NLR),单细胞/淋巴细胞比率 (MLR) 和血小板与淋巴细胞比率 (PLR) 在GDM预测中.
主要方法:
- 分析了635名患有GDM的孕妇和296名对照的队列.
- 评估了全面的CBC参数,炎症比率 (NLR,MLR,PLR) 和肝酶.
- 用接收器操作特征 (ROC) 曲线分析来确定诊断效率.
主要成果:
- 在GDM和对照组之间观察到WBC,中性细胞 (NEU),淋巴细胞 (LYM),单细胞 (MON),红细胞,HGB,PCT,ALT,AST,GT,NLR和MLR的显著差异 (P<0.05).
- 单细胞 (MON) 水平在所有评估因素中显示出最高的诊断准确性.
- 几种炎症标志物与GDM发展有相关性.
结论:
- 炎症因素,包括WBC,NEU,LYM,MON,NLR和MLR数量,与GDM有显著的相关性.
- 单细胞水平是早期GDM查的一个有希望的生物标志物.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Pathophysiology of Diabetes
918
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
918
Diabetes: Symptoms, Diagnosis, and Complications
521
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
521
Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
Hypoglycemia and Glucagon
254
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
254
Overview of Carbohydrate Metabolism
896
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
896


