欧蛋白对肉小具有低性作用
Usman Sulaiman1, Reagan Vaughan1, Paul Siegel1
1School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Frontiers in physiology
|June 27, 2024
概括
橄中的化合物欧蛋白 (oleuropein) 降低了肉的料摄入量和血糖. 这些发现表明,欧蛋白可以作为食欲抑制剂,并影响能量代谢.
科学领域:
- 动物科学动物科学
- 营养生物化学 营养生物化学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 橄中的类化合物欧在哺乳动物中表现出葡萄糖调节作用.
- 欧蛋白对鸟类,特别是肉的影响在很大程度上仍未得到研究.
研究的目的:
- 调查食欧蛋白补充剂和外源药物对肉小的料摄入量和葡萄糖恒温的影响.
- 为了确定oleuropein对肉体重和器官体重 (乳腺肌肉,肝脏) 的影响.
主要方法:
- brojiler接受了不同食度的欧蛋白 (0-1,000 mg/kg) 或腹腔内 (IP) 注射 (0-200 mg/kg).
- 给禁食的小注射了脑内静脉注射 (ICV),以评估对料摄入的中心影响.
- 给药后测量了料摄入量,血糖水平,体重和器官重量.
主要成果:
- 无论是IP还是ICV的oleuropein注射都显著降低了 brojiler小的料摄入量,效果在注射后60分钟最明显.
- 通过IP注射的较高剂量的欧蛋白导致注射后一个小时血糖水平降低.
- 在为期7天的研究期间,没有观察到对体重,乳腺肌肉或肝脏体重的显著影响.
结论:
- 欧蛋白在系统和中心的使用中,在肉中起轻微的食欲抑制作用.
- 欧蛋白通过影响家禽的料摄入量和血糖水平来影响能量代谢.
- 进一步的研究是有必要的,以探索在家禽生产中欧蛋白的具体机制和最佳应用.
相关概念视频
01:58Mechanical Protein Functions
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
02:11Proteins: From Genes to Degradation
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick. Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Transcription is the synthesis of RNA molecules by RNA...
01:29Protein Folding Quality Check in the RER
ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
01:58Mechanical Protein Function
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
02:11Proteins: From Genes to Degradation
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick. Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA molecules by RNA...
Transcription is the synthesis of RNA molecules by RNA...
01:28Protein Denaturation
The function of proteins depends on their native three-dimensional structure, which is dictated by the amino acid sequence of the specific protein. Folding of the polypeptide chain takes place under specific conditions that energetically favor the folded conformation. In contrast, protein denaturation occurs spontaneously under unfavorable conditions that disrupt the integrity of the folded conformation. Thus, the chemical and physical environment of a protein, such as significant changes in pH...