头骨和脊椎骨髓在中枢神经系统的炎症
1Department of Neurology, Tianjin Neurological Institute, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, International Joint Laboratory of Ocular Diseases, Ministry of Education, Haihe Laboratory of Cell Ecosystem, Tianjin Medical University General Hospital, Tianjin 300052, China.
Fundamental research
|June 27, 2024
概括
头骨和脊椎骨髓的免疫细胞可以通过血管道进入中央神经系统 (CNS),以维持免疫平衡并应对受伤. 本综述探讨了它们在中枢神经系统稳定性和疾病中的作用,帮助未来的治疗开发.
科学领域:
- 神经免疫学 神经免疫学
- 血液学 血液学 血液学
- 中枢神经系统 (CNS) 研究研究
背景情况:
- 来自骨髓的血液细胞有助于中枢神经系统 (CNS) 的免疫恒温.
- 头骨和脊椎骨髓有血液形成的,可以感知中枢神经系统的损伤.
- 这些提供免疫细胞,调节中枢神经系统的炎症反应.
研究的目的:
- 审查了解中枢神经系统中骨髓衍生免疫细胞的最新进展.
- 探索它们在中枢神经系统平衡和炎症疾病中的作用.
- 讨论神经系统疾病的治疗影响.
主要方法:
- 关于最近科学进展的文献综述.
- 分析血液细胞在中枢神经系统免疫调节中的作用.
- 综合与骨髓和中枢神经系统炎症相关的发现.
主要成果:
- 头骨和脊椎骨髓细胞通过骨化血管通道进入脑膜边界.
- 这些细胞对于维持中枢神经系统免疫恒温至关重要.
- 它们在中枢神经系统受伤后微调炎症反应中发挥作用.
结论:
- 来自骨髓的免疫细胞对于中枢神经系统的健康和疾病至关重要.
- 了解这些细胞为新的治疗策略提供了潜力.
- 针对这些途径可以减轻中枢神经系统的炎症和神经损伤.
相关概念视频
Cranial and Spinal Meninges
1.4K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
1.4K
Blood and Nerve Supply to the Bones
10.9K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
10.9K
Bone Marrow Sampling and Transplants
324
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
324
Cerebrospinal Fluid
2.1K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
2.1K
Sutures of the Skull
6.6K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
6.6K
Primary Lymphoid Organs
1.5K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.5K


