身体组成与乳腺癌患者新辅助化疗病理反应之间的关系
Aysun Isıklar1, Ebru Yilmaz2, Gul Basaran3
1Internal Medicine, Acıbadem Ataşehir Hospital, Istanbul, TUR.
Cureus
|June 27, 2024
概括
身体组成会影响乳腺癌 (BC) 中的新辅助化疗 (NAC) 反应. 麻症和肥胖症与较差的病理完整反应 (pCR) 率有关,这表明干预措施可能会改善结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 身体组成分析 身体成分分析
背景情况:
- 在可操作的乳腺癌 (BC) 中,新辅助化疗 (NAC) 反应与人体组成有关.
- 完整的病理反应 (pCR) 是接受NAC的BC患者的关键预后因素.
研究的目的:
- 评估身体构成,特别是BMI和骨肌肉质量对接受NAC的可手术BC患者的pCR的影响.
主要方法:
- 在诊断时接受CT成像的可手术的BC患者的回顾性分析.
- 肌肉质量从L3脊椎水平CT图像中量化.
- 身体组成数据与NAC反应和术后病理结果相关联.
主要成果:
- 在69名BC患者中,23%的患者实现了pCR.
- 麻患者的pCR率为37.5%,而非麻患者的pCR率为62.5% (p=0.530).
- 与正常体重患者相比,超重和肥胖患者的病理反应率较低 (p=0.261).
结论:
- 癌症和肥胖独立且协同预测乳腺癌中对NAC的病理反应较差.
- 针对身体构成的干预措施,如营养支持和运动,可以提高治疗结果.
- 需要对更大的队列进行进一步的研究,以验证这些发现并制定有针对性的战略.
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