在休息和运动后的健康男性中,八天的禁食会调节血清氨酸
Ulana Juhas1, Joanna Reczkowicz1, Jakub Antoni Kortas2
1Department of Bioenergetics and Physiology of Exercise, Medical University of Gdańsk, Gdańsk, Poland.
Frontiers in endocrinology
|June 27, 2024
概括
八天的禁食显著改变了kynurenine路径 (KP) 代谢物,增加了像皮科林酸 (PA) 和桑烯酸 (XA) 这样的关键化合物的度. 禁食后的运动进一步调节了这些KP代谢物水平.
科学领域:
- 生物化学 生物化学
- 人体生理学 人体生理学
- 代谢学 代谢学 代谢学
背景情况:
- 托芬 (Trp) 代谢物,特别是来自金氨酸 (KP) 途径的代谢物,是人类健康的新兴生物标志物.
- 已知禁食会影响Trp代谢物度,但对KP代谢物和运动相互作用的具体影响仍未得到充分研究.
研究的目的:
- 为了研究8天的禁食期对血清KP代谢物度的影响.
- 为了确定一个单一的耐力运动如何影响8天禁食后的KP代谢物.
主要方法:
- 一项涉及10名参与者进行8天的禁食和10名参与者的对照组的研究.
- 耐力运动是在基线 (在过夜禁食后) 进行的,并在8天禁食期间后重复进行.
主要成果:
- 禁食8天导致血清中3-基-L-kynurenine (3HK),picolinic acid (PA),kynurenic acid (KYNA) 和xanthurenic acid (XA) 的水平升高.
- 氨酸 (Phe) 和氨酸 (Tyr) 的升高表明,在禁食期间肌肉蛋白质的分解增加.
- 禁食后的运动降低了3-氨酸 (3HAA) 和PA度,对照组没有观察到这种效应.
结论:
- 禁食引起的健康益处可能与金氨酸路径的改变有关.
- 增加的PA和XA,可以穿越血脑屏障,以及KYNA,表明潜在的神经保护机制由禁食启动.
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