在中国成年人中,血清25-基维生素D与脂质谱之间存在非线性关系
Qianqian Wang1,2, Xinlei Miao1, Manling Hu3
1Health Management Center, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China.
Frontiers in nutrition
|June 27, 2024
概括
血清25-基维生素D [25(OH) D]水平显示与异常脂质样本的反向U形关联. 维生素D缺乏会增加脂质障碍的风险,特别是在冬季/春季或低紫外线指数期间的老年女性.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 心血管健康 心血管健康
背景情况:
- 之前对血清25-基维生素D[25(OH) D]和脂质配置文件的研究产生了不一致的结果.
- 这项研究旨在澄清25~OH) D水平和脂质配置文件之间的非线性关系.
研究的目的:
- 为了研究血清25(OH) D水平与各种脂质失调症之间的非线性关联.
- 为了确定与脂质异常相关的25(OH) D的特定切断点.
主要方法:
- 分析了大连健康管理队列 (DHMC) 中8,516名成年参与者的数据.
- 利用后勤回归,受限立方线和断片线性回归来评估25~OH) D级别的失脂症风险 (OR).
- 根据年龄,性别,季节和紫外线指数进行调整.
主要成果:
- 观察到高患病率的25...OH) D缺乏症 (65.05%).
- 在25OH) D水平和异常脂质配置文件的风险之间发现了反向U形相关性.
- 各种脂质失调症的点在18.5~24.3 ng/ml之间.
- 与25OH) D缺乏相关的大多数脱脂症的风险增加在50-74岁的女性中显著,在冬季/春季,或在低/中等紫外线指数下.
结论:
- 非线性,反向的U形关联存在于25(OH) D水平和异常的脂质配置文件之间.
- 维生素D缺乏会显著增加脂质障碍症的风险,特别是在特定的人口和环境条件下.
- 需要进一步的研究来探索维生素D水平与缺乏维生素D的人群中脱脂症风险之间的积极关联.
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