杀菌/增加透性的蛋白质的血水平与急性冠状动脉综合征的全身炎症相关
Shicheng Yu1, Haoxuan Jia2, Zheng Li2
1Department of Cardiology, Lu'an Hospital of Anhui Medical University, Lu'an, Anhui, 237000, PR China.
Heliyon
|June 27, 2024
概括
在急性冠状动脉综合征 (ACS) 患者中,细菌杀菌/增加透性的蛋白质 (BPI) 的血水平显著更高. BPI显示出作为ACS诊断生物标志物的潜力,与疾病严重程度和炎症相关.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 中性粒细胞与动脉样硬化和动脉血症有关.
- 细菌杀菌/增加透性的蛋白质 (BPI) 在炎症期间由中性粒细胞表达.
- 这项研究研究了急性冠状动脉综合征 (ACS) 患者的血BPI水平.
研究的目的:
- 在ACS患者中评估血BPI水平.
- 为了将BPI水平与中性粒细胞计数和炎症生物标志物相关联.
- 评估BPI对ACS和心肌梗塞的诊断疗效.
主要方法:
- 367名患有急性胸痛的患者的截面研究.
- 血BPI,IL-1β,MPO-DNA,hs-CRP和S100A8/A9通过ELISA进行测量.
- 与临床评分 (TIMI,GRACE,Gensini) 和进行的ROC分析的相关性.
主要成果:
- ACS患者的血BPI水平明显高于非ACS患者.
- 血BPI与ACS严重程度得分和炎症标志物正相关.
- 在ACS和心肌梗塞的诊断中,BPI的诊断效果与已知标志物相匹配.
结论:
- 在ACS中,BPI与全身炎症有关.
- BPI可能在动脉样硬化和动脉栓症中发挥作用.
- 作为ACS预后和诊断生物标志物,需要对BPI进行进一步的临床研究.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
76
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
76
Inflammation
53.3K
Overview
53.3K
Antimicrobial Proteins
975
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
975
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
136
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
136
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
4.9K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
4.9K


