用多束激光振动计测量带关节脉冲波速的临床验证:CARDIS研究
Smriti Badhwar1, Louise Marais1, Hakim Khettab2
1Paris Cardiovascular Research Center (PARCC) Institut National de la Santé Et de la Researche Médicale (INSERM), Paris, France (S.B., L.M., F.P., R.M.B., P.B.).
Hypertension (Dallas, Tex. : 1979)
|June 27, 2024
概括
一种新的激光多普勒振动计 (LDV) 装置准确地测量了带 - 关节脉冲波速率 (cfPWV),这是动脉刚性的关键指标. 这种经过验证,独立于操作者的方法为临床评估心血管疾病风险提供了更简单的替代方案.
科学领域:
- 生物医学工程 生物医学工程
- 心血管生理学心血管生理学
- 医学诊断 医学诊断 医学诊断
背景情况:
- Carotid-femoral脉冲波速率 (cfPWV) 是评估动脉硬性的黄金标准,这是心血管疾病 (CVD) 的关键独立预测因素.
- 目前的临床实践缺乏常规cfPWV测量,原因是缺乏具有成本效益,用户友好和独立的设备.
- 动脉硬度评估对于指导心血管健康治疗干预至关重要.
研究的目的:
- 验证一种基于激光多普勒振动计 (LDV) 的新型装置,用于测量cfPWV与已建立的参考技术相比.
- 评估在临床环境中使用LDV进行非侵入性动脉硬度测量的可行性.
- 评估LDV衍生的cfPWV与心血管风险得分的相关性.
主要方法:
- 在100名高血压患者中测量了cfPWV,这些患者使用了平面度计 (Sphygmocor) 和一种新型的LDV设备,配有双手柄激光系统.
- 该LDV装置同时捕获动脉和大腿动脉的皮肤表面振动,通过依赖心电图和独立方法计算脉冲波速度.
- 用40-75岁患者的世卫组织风险评分表来计算心血管风险.
主要成果:
- 基于LDV的cfPWV与度测量结果有显著的相关性 (r=0.86,P<0.0001对于依赖心电图;r=0.80,P<0.001对于独立心电图).
- 布兰德-阿尔特曼分析显示,LDV和度测量方法之间没有显著偏差 (0.65 m/s) 和可接受的一致性 (SD=1.27 m/s).
- 观察到cfPWV (通过这两种方法测量) 和心血管疾病风险得分之间存在显著的相关性.
结论:
- 该LDV设备是临床验证为一个简单的,非侵入性的,和操作员独立的工具来测量cfPWV.
- LDV方法提供与标准技术相比的动脉硬度评估,提高了临床实用性.
- 这项技术有可能在临床实践中促进常规cfPWV测量,以改善心血管风险分层.
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