相关实验视频
Updated: Jun 22, 2025
13:08
Creation and Maintenance of a Living Biobank - How We Do It
Published on: April 10, 2021
7.4K
国家卫生研究院COVID-19神经数据库/生物库:创造和进化
Sharon B Meropol1, Cecile J Norris2, Jennifer A Frontera3
1Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine, New York, New York, USA.
Neuroepidemiology
|June 27, 2024
概括
在COVID-19感染后,神经系统症状很常见. COVID-19神经数据库 (NeuroCOVID) 创建了一个庞大而多样化的数据集,以研究这些持续的神经疾病.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 数据科学数据科学数据科学
背景情况:
- 感染SARS-CoV-2经常导致神经症状,20%的患者在感染后六个月经历了持续的问题.
- 目前对COVID-19相关神经系统疾病的研究受限于小型的局部患者队列.
研究的目的:
- 建立COVID-19神经数据库 (NeuroCOVID) 作为一个科学资源.
- 收集详细,精心策划和协调的非识别数据,从一个庞大,多样化的成年人群中收集,这些成年人患有与COVID-19疾病相关的新发病或恶化的神经疾病.
主要方法:
- 招募了各种各样的美国和国际研究地点,包括学术/非学术和城市/非城市地点.
- 开发了一个REDCap数据库,包含专家的意见,专业指南和共同的数据元素.
- 通过使用标准化病例报告表格,从超过2700名患者的医疗记录中提取了非身份化数据.
主要成果:
- 现在NeuroCOVID数据库包括来自16个美国和5个国际站点的2700多个患者记录.
- 数据收集一直是响应不断变化的科学兴趣,特别是后急性疾病及其时间.
- 数据正在与科学界分享,并向国家医学图书馆提供病例报告表格.
结论:
- 神经COVID数据库为研究与COVID-19相关的各种神经疾病提供了一个独特而有价值的资源.
- 这些数据支持科学努力,以表征和治疗COVID-19的神经后果.
- 该项目展示了一个成功的合作模式,大规模收集数据以应对全球卫生危机.
相关概念视频
00:36Viral Mutations
32.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.2K
02:02Genomics
36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.3K
01:12Statistical Software for Data Analysis and Clinical Trials
532
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
532
01:05Single Nucleotide Polymorphisms-SNPs
15.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.0K
01:30Introduction to Biological Bases of Psychology
3.2K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.2K