通过功能性MRI了解REM睡眠行为障碍:系统性审查
Lachlan Churchill1, Yu-Chi Chen2, Simon J G Lewis3
1Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
概括
功能磁共振成像 (fMRI) 揭示了快速眼动睡眠行为障碍 (RBD) 的早期神经退行,这是帕金森病 (PD) 的前兆. 这些发现提供了关于勒维体疾病进展和潜在生物标志物的见解.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 快速眼动睡眠行为障碍 (RBD) 是帕金森病 (PD) 等同核蛋白病变的前兆标记.
- 功能磁共振成像 (fMRI) 对神经退行性疾病中的早期神经网络变化敏感.
研究的目的:
- 在RBD患者中综合所有fMRI研究的发现,以了解Lewy体疾病的病理生理学和进展.
- 为了确定孤立的RBD (iRBD) 和二次 PD 的RBD 中常见的功能性改变.
主要方法:
- 在iRBD或RBD患者的PD中对32项原始fMRI研究进行系统审查,遵守PRISMA指南 (2000年1月至2024年2月).
- 分析大脑区域和全脑网络的功能连接性变化.
主要成果:
- 与对照人群相比,iRBD患者在脑干,基底,额叶/叶以及全脑网络中表现出功能性改变.
- 患有RBD的PD患者表现出全脑和脑干连接性下降,但大脑小脑和额头连接性增加,与没有RBD的PD相比.
- 纵向fMRI数据表明,静止状态的功能连接性变化与疾病进展相关.
结论:
- fMRI检测到RBD中运动和非运动通路中的早期神经退行性特征.
- 在RBD中fMRI具有区分前性PD与利维体前性痴呆症的潜力.
- 基于fMRI的措施可以作为疾病修饰疗法的临床试验的结果.
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