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Updated: Jun 22, 2025

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抑制eEF2酸化缓解了唐氏综合征小鼠模型中的突触失败和认知缺陷

Xin Wang1, Qian Yang1, Xueyan Zhou1

  • 1Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|June 27, 2024
PubMed
概括

唐氏综合症 (DS) 涉及与过度活跃的eEF2K信号传递相关的认知障碍. 在DS模型中抑制这种激酶改善了蛋白质合成,突触功能和认知缺陷,提供了潜在的治疗点.

关键词:
唐氏综合征是什么意思 唐氏综合征认知 认知 认知单核细胞延长因子2酶鼠标模型 鼠标模型鼠标模型蛋白质合成 蛋白质合成突触性可塑性 突触性可塑性

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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