患有睡眠障碍的COVID-19患者灰质持续变化:为期3个月的纵向研究
Kaixuan Zhou1,2, Gaoxiong Duan2, Ying Liu2
1Guangxi Key Laboratory of Special Biomedicine; School of Medicine, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region, China.
Neural regeneration research
|June 27, 2024
概括
患有睡眠障碍的COVID-19患者在急性感染期间在多个叶部显示大脑结构变化. 随访显示,前额外皮层持续发生变化,影响睡眠质量.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍是COVID-19后常见的神经心理症状.
- 以前的研究集中在长期影响上,对COVID-19相关睡眠问题的急性阶段数据有限.
- 关于COVID-19和睡眠障碍的神经成像研究很少.
研究的目的:
- 为了调查COVID-19患者的急性阶段大脑结构变化与睡眠障碍.
- 在感染后3个月内检查大脑结构的纵向变化.
- 了解COVID-19急性阶段睡眠障碍的病理生理学.
主要方法:
- 纵向神经成像研究将COVID-19患者与健康对照者进行比较,包括睡眠障碍和没有睡眠障碍的患者.
- 分析包括大脑结构变化 (皮层厚度,体积) 和与睡眠质量得分 (匹兹堡睡眠质量指数) 的相关性.
- 感染后3个月的后续评估评估评估了持续的结构变化.
主要成果:
- 患有睡眠障碍的COVID-19患者在脑叶中表现出广泛的大脑结构变化.
- 在皮层厚度 (左侧骨干,左侧骨干) 和睡眠质量得分之间发现了显著的负相关性.
- 在3个月的随访期间观察到海马体积变化和持续的前额-双叶皮层变化.
结论:
- 在急性感染期间,COVID-19患者有睡眠障碍,皮质和海马体形态变化.
- 感染后3个月,前额外皮层中持续的大脑结构变化显而易见.
- 这些发现增强了对COVID-19相关睡眠障碍的神经生物学基础的理解.
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