非神经性男性LUTS/BPH的尿道和前列腺微生物组:系统性审查
Teresa Pina-Vaz1,2, Alberto C Silva1,2, Carlos Silva1,2
1Department of Urology, Centro Hospitalar de São João, Porto, Portugal.
Neurourology and urodynamics
|June 27, 2024
概括
男性的尿道微生物组与良性前列腺激增症 (BPH) 和下尿道症状 (LUTS) 有关. 失生症,特别是菌和血球菌,与症状严重程度相关,表明潜在的微生物组向疗法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 良性前列腺增生症 (BPH) 的机制尚未完全理解,其中涉及前列腺炎症,但其触发因素不明.
- 与BPH相关的下尿路症状 (LUTS) 可能受到尿路微生物群的影响.
- 新出现的证据表明,尿路微生物组失调是BPH发展和进展的潜在因素.
研究的目的:
- 系统地审查男性尿道和前列腺微生物组与BPH/LUTS之间的关系.
- 探索微生物失生症在BPH和LUTS病理生理学中的潜在作用.
主要方法:
- 在PubMed和Scopus数据库中进行系统的文献搜索.
- 纳入标准侧重于由于BPH和尿路微生物组分析而患有LUTS的男性非神经性患者.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 七项涉及542名患者的研究表明,男性尿道微生物组与LUTS/BPH之间存在关联.
- 尿道微生物组失调与LUTS严重程度相关,特定的细菌与较高的症状得分和PSA水平有关.
- 指出了便微生物组和LUTS之间的潜在联系,尽管发现不一致;确定了方法限制.
结论:
- 微生物组与LUTS/BPH之间存在明显的相关性.
- 标准化采样技术和功能性微生物群的表征对于未来的研究至关重要.
- 针对BPH的微生物组向治疗策略需要进一步研究.
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