相关实验视频

Updated: Jun 22, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

在BCL2相互作用蛋白3像 (BNIP3L) 遗传多态性和中国多发性骨髓瘤风险之间的关联

Qicai Wang¹, Yu Wang¹, Jing Wu²

¹Department of Laboratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's Republic of China.

Hematology (Amsterdam, Netherlands)

|June 27, 2024

概括

BNIP3L rs2874670单核酸多态性 (SNP) 与增加多发性骨髓瘤 (MM) 风险有关. 特定的BNIP3L基因型也可能影响化学治疗后MM患者的预后.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

该BCL2相互作用蛋白3类 (BNIP3L) 蛋白质在多发性骨髓瘤 (MM) 发病过程中发挥作用.
调查BNIP3L的遗传变异可能会揭示MM易感性和进展的新见解.

研究的目的:

探索BNIP3L基因中的单核酸多态 (SNPs) 与患多发性骨髓瘤的风险之间的关联.
评估BNIP3LSNP对MM患者预后的影响.

主要方法:

在注册受试者中使用SNaPshot方法对6个BNIP3L SNP位点进行基因型定型.
统计分析,包括生存分析和考克斯回归,以评估SNP,MM风险和患者结局之间的关系.
评估预后因素,如R-ISS分期,化疗,自身干细胞移植,LDH和β2-MG水平等.

主要成果:

rs2874670 AA基因型和BNIP3L的A等位基因与MM的风险增加显著相关 (P<0.05).
特定的BNIP3L单元型 (CCACAC和CCGCAC) 显示MM患者和健康对照人群之间的频率差异 (P <0.05).
预后因素包括R-ISS阶段,治疗方式 (化疗±ASCT),LDH和β2-MG水平显著影响了患者的生存率 (P <0.05). 经过BD化疗后,在MM患者与不同的rs2874670基因型之间观察到生存时间的显著差异 (P <0.05).

结论:

这项研究确定BNIP3L rs2874670是中国人群中多发性骨髓瘤易感性的潜在遗传风险因素.
BNIP3L rs2874670基因型可能会影响接受特定化疗方案的MM患者的临床预后,如BD化疗.

关键词:

在BNIP3L中.多发性骨髓瘤是多发性骨髓瘤的一种.多态的多态化.生存分析,生存分析.易感性易感性易感性

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

相关概念视频

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...