失眠症状与阿尔茨海默氏病之间的相互作用跨越了三个主要的大脑网络
Jorik D Elberse1,2,3, Amin Saberi1,2,4, Reihaneh Ahmadi1,5
1Institute of Neuroscience and Medicine, Brain and Behavior (INM-7), Research Center Jülich, Jülich, Germany.
Sleep
|June 27, 2024
概括
失眠症状显著改变阿尔茨海默病 (AD) 患者的大脑连接,显示网络连接减少. 这突出了AD与失眠的功能性大脑变化的独特模式.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 医疗成像医学成像
背景情况:
- 失眠症状在阿尔茨海默氏病 (AD) 进展中很常见.
- 在阿尔茨海默病中失眠的神经生物学基础尚未得到充分理解.
研究的目的:
- 为了调查阿尔茨海默病 (AD) 中失眠的神经生物学基础.
- 为了检查与失眠和AD诊断有关的结构和功能大脑网络变化.
主要方法:
- 来自ADNI数据库的320名参与者被分类为认知正常 (CN),轻度认知障碍 (MCI) 或AD,有或没有失眠.
- 评估灰色物质体积 (GMV),结构共变性 (SC),中心度 (DC) 和功能连接性 (FC).
- 分析了失眠和诊断对大脑测量的影响和相互作用,将发现与认知和情感得分相关联.
主要成果:
- 在所有诊断组中,失眠症状与功能连接 (FC) 改变相关.
- 认知正常 (CN) 和轻度认知障碍 (MCI) 群体表现出网络内部的高连接性与失眠;AD患者表现出广泛的网络内部和网络之间的低连接性.
- 结构共变 (SC) 和灰质体积 (GMV) 的变化与失眠无关;在AD患者的中央执行网络 (CEN) 中注意到程度中心性 (DC) 的变化.
- 在默认模式网络 (DMN) 和CEN枢纽中改变FC与AD的认知衰退和抑郁症状增加有关.
结论:
- 临床阿尔茨海默病患者表现出与失眠相关的功能性大脑变化的独特模式.
- 失眠和阿尔茨海默病病理影响大脑网络之间存在显著的相互作用.
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