相关实验视频
Updated: Jul 22, 2026

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Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
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在小鼠中, Locus coeruleus 的激活会导致masseter 肌肉过度活跃,这种过度活跃是由慢性克制压力引起的
Yang Liu1, Ji Chen2,3, Qiang Li1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry and Emergency, School of Stomatology, The Fourth Military Medical University.
Neuroreport
|June 27, 2024
概括
压力会导致部肌肉过度活跃,这与关节障碍有关. 这项研究表明,激活大脑中的神经元 (locus coeruleus) 有助于应激诱导的肌问题和焦虑.
科学领域:
- 神经科学是一个神经科学.
- 压力研究 压力研究
- 面部疼痛机制 面部疼痛机制
背景情况:
- 压力与口腔面部肌肉过度活动和关节障碍 (TMD) 有关.
- 精确的中枢神经通路调解压力诱导的肌肉过度活动仍然在很大程度上是未知的.
- 核心位置 (locus coeruleus) 与应激反应和行为变化有关.
研究的目的:
- 为了研究 locus coeruleus神经元在压力诱导的按摩器肌肉过度活动中的作用.
- 阐明连接压力,焦虑和耳面肌肉功能的中枢神经机制.
主要方法:
- 建立了一种慢性克制压力的小鼠模型.
- 行为测试评估了类似焦虑的行为.
- 使用电肌图 (EMG) 来测量马塞特肌肉活动.
- 在coeruleus位置的神经元激活通过Fos表达量化.
- 化学遗传技术被用来抑制 locus coeruleus 神经元活动.
主要成果:
- 在老鼠中,慢性压力诱导了类似焦虑的行为和masseter肌肉过度活跃.
- 压力显著地激活了神经元在位置 coeruleus.
- 抑制神经元局部 (locus coeruleus) 和神经元 noradrenergic 活动减少了压力诱导的焦虑和masseter 肌肉过度活动.
结论:
- 位于神经位 (locus coeruleus) 中的诺拉德仁基神经元的激活是压力诱导的焦虑和马塞特肌肉过度活性的关键中心机制.
- 准coeruleus位置可能为与压力相关的TMD症状提供治疗潜力.
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