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氧化物纳米颗粒作为一种多功能,杀菌,抗氧化和抗增殖剂,对抗破坏性病原体

P Prapula Thejashwini¹, R Chandrika¹, M C Madhusudhan¹

¹Nanobiotechnology Laboratory, DOS in Biotechnology, University of Mysore, Manasagangotri, Mysuru, 570006, Karnataka, India.

Bioprocess and biosystems engineering

|June 27, 2024

概括

生物灵感的氧化纳米颗粒 (ZnO NPs) 由瓜叶合成,显示出强大的抗菌和抗氧化活性. 这些环保的ZnONP还显示出抗癌潜力,为新药开发铺平了道路.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物技术是生物技术.

背景情况:

生物启发的氧化纳米颗粒 (ZnO NPs) 越来越多地研究其安全性,成本效益和生物多样性.
基于植物的纳米粒子合成提供了一种环保,简单,无毒的方法.

研究的目的:

为了合成氧化纳米颗粒 (ZnO NPs) 使用Psidium瓜叶提取物.
描述合成的 ZnO NPs 并评估它们的生物特性,包括抗微生物,抗氧化剂和抗增殖活性.

主要方法:

从Psidium guajava水性叶子提取物中合成ZnONP的自下而上的合成.
使用UV-Vis,XRD,EDX,FT-IR,DLS,SEM和HR-TEM进行结构和形态表征.
对抗微生物 (MIC,MBC),生物膜破坏,抗氧化剂 (IC50) 和抗增殖试验的评估.

主要成果:

合成的 ZnO NPs 呈现出水力动态形状,颗粒大小范围为 11.6-80.2 nm.
对Enterococcus faecalis,Staphylococcus aureus,Staphylococcus mutans和Candida albicans具有显著的抗菌活性. 这种抗菌物质具有很强的抗菌活性.
证明有效地破坏了Streptococcus mutans和Candida albicans生物膜.
呈现出强大的剂量依赖的抗氧化活性 (IC50 = 9.89 μg/ml) 和对MDA MB 231癌细胞的抗增殖作用.

结论:

这项研究成功地从Psidium瓜叶提取物中合成和特征化了环保ZnONP.
生物合成的ZnONP具有显著的抗微生物,抗氧化剂和抗癌性质.
这些发现凸显了植物衍生的ZnONP在制药应用中的潜力,特别是在药物耐药性和癌症治疗方面.

关键词:

P. 瓜亚瓦瓦瓦瓜亚瓦瓦瓜亚瓦具有抗氧化活性的抗氧化剂.生物膜检测试验方法生物合成生物合成标志性描述标志性描述在MDA MB 231中使用.在MTT测试中使用MTT测试.ZnO NPs的使用情况.

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