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在可切除局部先进的口腔状细胞癌中进行新辅助化学免疫疗法:单中心回顾性队列研究

Bowen Li^1,2, Shule Xie^1,2, Jingjing Han³

¹Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University.

International journal of surgery (London, England)

|June 27, 2024

概括

新辅助化疗免疫疗法 (NACI) 在局部发达的口腔状细胞癌 (OSCC) 中显示出有前途的疗效和安全性. 与标准治疗相比,这种治疗显著提高了无疾病和整体存活率.

科学领域:

在瘤学瘤学.
癌症研究癌症研究
免疫治疗是一种免疫疗法.

背景情况:

可切除口腔状细胞癌 (OSCC) 的标准治疗包括手术和辅助疗法.
新辅助化疗免疫疗法 (NACI) 正成为一种潜在的优越治疗方式.
本研究评估了针对局部先进切除性OSCC的NACI疗法.

研究的目的:

调查新辅助化疗免疫疗法 (NACI) 在局部晚期可切除口腔状细胞癌 (OSCC) 的有效性.
评估与NACI治疗相关的病理反应,生存率和不良事件.

主要方法:

在2020年12月至2022年6月期间接受NACI的104名局部高级切除OSCC患者的回顾性审查.
评估病理反应,与治疗相关的不良事件 (TRAE) 使用常用术语标准对不良事件v5.0.0.
评估无病生存率 (DFS) 和整体生存率 (OS).

主要成果:

NACI实现了病理完整反应率为47.1%,主要病理反应 (MPR) 率为65.4%.
常见的TRAE包括脱发 (100%),贫血 (77.9%) 和 (59.6%).
与较高的PD-L1 CPS相关的MPR,以及与总胆固醇结合的CPS显示了NACI疗效的诊断价值. 三年DFS和OS率在NACI队列 (89.0%和91.3%) 与非NACI队列 (60.8%和64.0%) 相比显著更高.

结论:

NACI证明了局部先进切除性OSCC的安全有效的治疗选择.
高响应率和有利的生存结果支持NACI作为潜在的治疗策略.
通过潜在的随机对照试验进行进一步验证是有必要的.

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