皮肤状细胞癌的分级差异化:文献综述
Claire Diede1, Trent Walker2, David R Carr3
1University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, USA.
Archives of dermatological research
|June 27, 2024
概括
标准化对皮肤状细胞癌 (CSCC) 差异化的分级至关重要. 目前不一致的分级影响了这种高风险皮肤癌的分期和患者风险评估.
科学领域:
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 皮肤状细胞癌 (CSCC) 的差差分化与不良结果相关.
- 国家综合癌症网络的指导方针将差异化不良的CSCC归类为"非常高风险".
- 目前的CSCC差异化分级缺乏标准化,并且在皮肤病理学家和莫斯外科医生中表现出差的inter-和intra-rater可靠性.
研究的目的:
- 审查CSCC差异化的历史和当前分级系统.
- 检查用于非皮肤头部和部状细胞癌的分级系统作为参考.
- 突出需要一个可靠和标准化的CSCC差异化分级系统.
主要方法:
- 关于Embase和PubMed数据库的综合文献评论.
- 包括从已识别的文章和组织学教科书摘录的参考清单.
- 已识别的CSCC分级系统的总结,包括历史和基于共识的方法.
主要成果:
- 确定和总结了多个CSCC差异化分级系统.
- 历史系统 (例如,Broders) 和当代系统 (例如,WHO,CAP,Delphi共识) 被审查.
- 不一致的应用和可靠性问题困扰着目前的CSCC差异化等级.
结论:
- 目前没有标准化和可靠的分级系统来区分CSCC.
- 缺乏标准化的分级阻碍了其融入CSCC分期和风险分层.
- 开发基于共识的可靠分级系统是必要的,以改善患者管理和结果.
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