成年期体重变化模式与骨关节炎风险有关:一项基于人口的研究
Aiyong Cui1, Jun Zhang1, Hongli Deng1
1Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.
Aging clinical and experimental research
|June 27, 2024
概括
在成年期保持正常体重对于降低骨关节炎风险至关重要. 体重变化,包括体重增加或减轻,与骨关节炎发病率的增加有关,特别是对于那些仍然肥胖的人来说.
科学领域:
- 风湿病学和整形外科
- 公共卫生和流行病学
- 体重管理和代谢健康
背景情况:
- 体重是已知的骨关节炎 (OA) 的风险因素.
- 关于体重状况在成年期对OA风险的长期影响的研究有限.
- 本研究研究了至少25年的体重变化模式及其与OA的关联.
研究的目的:
- 调查整个成年期体重变化模式与患骨关节炎 (OA) 的风险之间的关联.
- 分析50岁以上个人2013-2018年国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 对7392名50岁以上的成年人至少25年的体重变化模式的分析.
- 使用多变量线性回归模型来评估体重变化和自我报告的OA之间的关系.
- 限制性立方线 (RCS) 用于评估绝对体重变化与OA风险之间的非线性关联.
主要成果:
- 从肥胖转变为非肥胖的个体有1.34倍的关节炎风险;从非肥胖转变为肥胖的个体有1.61倍的风险.
- 成年期稳定的肥胖与稳定的正常体重相比,与OA风险增加1.82倍有关.
- 在绝对体重变化和OA风险之间观察到U形关系,表明显著的体重波动增加了风险.
结论:
- 整个成年期的体重模式显著影响患骨关节炎的风险.
- 保持稳定,正常的体重对于预防OA至关重要.
- 防止体重增加,特别是在成年早期,对于减轻长期OA风险至关重要.
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