药解体和毒解体的结构-活性关系:需要临床策略
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of Agriculture, Makurdi, P.M.B. 2373, Benue State, Nigeria. pharn_saga2006@yahoo.com.
概括
了解药物的疗效和毒性至关重要. 这项研究确定了影响治疗效果和不良反应的关键化学特性和功能组,指导开发更安全,更有效的药物.
科学领域:
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
- 药物发现 药物发现 药物发现
背景情况:
- 预测治疗剂的长期临床疗效和毒性是一项挑战.
- 有必要进行文献分析,以了解药物的毒性和降低疗效.
- 确定影响药物安全性和有效性的因素对于临床实践至关重要.
研究的目的:
- 进行文献搜索,以评估临床药物的毒性和降低疗效的原因.
- 识别具有高效率和相对较低毒性的化学化合物.
- 探索化学性质,药理性质,毒理性质和药物结果之间的关系.
主要方法:
- 在数据库 (PubMed,Scopus,科学网等) 的文献搜索. 从1960年到2023年. 从1960年到2023年.
- 包括详细描述物理化学性质,化学公式,分子质量,pH,电离,受体相互作用和结构-活性关系的手稿.
- 关键词:药,毒,结构-活性-关系,疾病; 排除:缺乏药/毒的化学物质,1960年以前的出版物.
主要成果:
- 药理和毒理组决定治疗疗效和安全性;重叠导致并发效应.
- 药物的疗效和毒性取决于功能组,剂量,药物与受体相互作用和结合时间.
- 分子质量,化学结构,pH值,受体亲和力,多种药和脂性显著影响活性.
结论:
- 通过每天一次治疗,可以最大限度地降低毒性和提高疗效.
- 建议避免可逆药理学,并使用具有共价 adducts 的药物.
- 对于绝症,采用多种药理和维持治疗剂量是关键策略.
关键词:
化学结构 化学结构药物设计 药物设计有效性 有效性.药科类动物 (Pharmacophore) 是一种药科类动物.安全的安全的安全的安全的安全.毒素食者 (Toxicophore) 是一种有毒的动物.更多相关视频
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