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博障碍中的前额白色和灰色物质异常:多式核磁共振成像研究
Albert Bellmunt-Gil1,2, Victor Vorobyev3, Riitta Parkkola3
11Turku Brain and Mind Center, University of Turku, Turku, Finland.
Journal of behavioral addictions
|June 27, 2024
概括
博障碍 (GD) 与前-上-下丘脑电路中的白质完整性降低有关,类似于物质使用障碍. 这表明成的共同神经基础,独立于药物使用.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 神经成像是一种神经成像.
背景情况:
- 在像博障碍 (GD) 这样的行为成中,大脑结构连接的作用尚不清楚.
- 在没有药理学混的情况下,GD可以作为研究成机制的模型.
研究的目的:
- 通过使用多式核磁共振 (MRI) 来调查患有GD的人的白质 (WM) 完整性.
- 为了探索前-三-胸膜电路在GD病理生理学的参与.
主要方法:
- 多种模式的MRI (T1,T2,FLAIR,DWI) 用于20名患有GD和40名健康对照 (HCs) 的个人.
- 分析包括WM完整性 (微分异型,病变负载) 和灰质 (GM) 形态学.
- 研究了神经成像发现与GD症状严重程度之间的相关性.
主要成果:
- 患有GD的个体表现出WM整体性在前部区域 (冠状炎,体) 的降低和WM病变负载的增加.
- 在GD组中观察到左丘脑中更低的GM体积和左轨道前皮层中更低的GM厚度.
- 特定的额头部区域的WM完整性与博症状严重程度有负相关性.
结论:
- 额头 - 两 - 胸膜电路与GD有关,反映了物质使用障碍的发现.
- 这些结果表明,这种神经回路在成中起着至关重要的作用,而不管物质参与.
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