微生物群和宿主生物在合作和竞争之间切换,基于饮食中的铁含量
Marie-Louise Noordine1,2, Yohannes Seyoum1,3,4, Aurélia Bruneau1,2
1Micalis Institute, Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), AgroParisTech, Université Paris-Saclay, UMR1319, Jouy-en-Josas, France.
Gut microbes
|June 27, 2024
概括
当铁丰富时,肠道微生物群有助于储存铁,但当铁稀缺时,通过抑制铁的吸收来与宿主竞争. 饮食中的铁含量显著改变宿主微生物群相互作用和肠道健康.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群在宿主营养处理中起着至关重要的作用,包括铁代谢.
- 主体微生物群相互作用是复杂的,可以受到饮食因素的影响,例如铁的可用性.
研究的目的:
- 研究饮食中的铁含量如何调节消化道中宿主-微生物群相互作用.
- 了解铁的可用性对铁的吸收和储存机制的影响,受微生物群的影响.
主要方法:
- 无细菌 (GF) 和常规 (SPF) 的小鼠与富含铁或缺乏铁的饮食进行比较.
- 在十二指肠,肝脏和肺部分析铁血参数,费里丁和Dmt1表达.
- 在缺乏铁的条件下评估微生物群组成和多样性变化.
- 用特定的细菌注射GF小鼠以研究宿主微生物群相互作用.
主要成果:
- 微生物群在富含铁的饮食中增强了铁的储存 (血红蛋白,肝素,肠道费里丁).
- 在缺乏铁的饮食中,微生物群抑制了肠道Dmt1的表达,可能是通过Hif-2α.
- 在十二指肠,肝脏和肺部观察到对微生物群和铁可用性的器官特异性反应.
- 铁耗尽改变了微生物群的组成,减少了α多样性,增加了乳酸菌群的丰富性.
- 这种缺乏铁的宿主有利于Bifidobacterium longum的肠道健康.
结论:
- 肠道微生物群动态调节宿主铁的稳态,在铁丰富时协助储存,在铁稀缺时竞争吸收.
- 饮食中铁的可用性显著影响宿主微生物群的相互作用,影响肠道上皮的功能和微生物群体结构.
- 了解这些相互作用对于管理铁状况和肠道健康至关重要.
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