在坦桑尼亚达累斯萨拉姆的女性酒吧工作者中展示有效启动和保留暴露前预防 (PrEP) 的服务交付模型:双重随机干预研究协议
Joy J Chebet1, Winfrida Onesmo Akyoo2, Hannah Goymann3
1Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, United States of America.
PloS one
|June 27, 2024
概括
这项研究调查了女性酒吧工作者在工作场所的暴露前预防 (PrEP) 交付,旨在改善艾滋病毒预防的准入和遵守. 这些发现可以显著减少弱势群体的艾滋病毒感染.
科学领域:
- 公共卫生 公共卫生
- 预防传染病 预防传染病
- 临床试验 临床试验
背景情况:
- 暴露前预防 (PrEP) 是有效的预防艾滋病毒感染.
- 女性酒吧工作者 (FBWs) 因工作和非正式性工作而面临艾滋病毒的高风险.
- 工人面临着很大的障碍,无法获得基于设施的PrEP服务.
研究的目的:
- 为了比较基于工作场所的PrEP提供与标准的基于设施的PrEP启动,保留和遵守FBWs之间的护理.
- 评估一项全道PrEP冠军干预措施在改善PrEP遵守方面的有效性.
主要方法:
- 这是一项双随机干预研究,涉及查,同意和6个月的PrEP启动 (emtricitabine/tenofovir disoproxil).
- 参与者在酒吧层面随机选择,在工作场所或医疗机构接受PrEP.
- 个人随机化为可选的PrEP冠军干预来增强坚持;每月后续检查,艾滋病毒检测和尿液TDF检测.
主要成果:
- 主要结局包括PrEP启动率和坚持 (可检测的尿液TDF在6个月).
- 治疗意向 (ITT) 分析将用于初级结果评估.
- 该研究旨在选1,205名FBW,以招募至少160名HIV阴性女性.
结论:
- 该研究将评估两项干预措施,以减少FBWs中PrEP吸收和保留障碍.
- 成功的干预措施可以显著帮助减轻非洲的艾滋病毒流行病.
- 这项研究解决了对弱势群体可访问的艾滋病毒预防策略的关键需求.
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