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除了症状之外:对单边和双边的巨细胞轻度自主皮质醇分泌的比较分析
Tugba Barlas1, Isil Imge Gultekin2, Sabri Engin Altintop1
1Department of Endocrinology and Metabolism, Gazi University, Faculty of Medicine, Ankara, Turkey.
Clinical endocrinology
|June 27, 2024
概括
与单边的MACS相比,双边宏粒体轻度自主皮质醇分泌 (MACS) 的患者表现出较低的脱水氨硫酸 (DHEA-S) 水平和较高的2型糖尿病 (T2DM) 和高胆固醇血症率. 在MRI上的信号强度指数 (SII) 不区分单边和双边MACS.
科学领域:
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 轻度自主皮质醇分泌 (MACS) 是一种以过度皮质醇产生为特征的疾病.
- 马克隆状上腺增生可以呈现为单边或双边疾病.
- 区分单边和双边MACS对于临床管理很重要.
研究的目的:
- 为了比较临床,实验室和MRI信号强度指数 (SII) 在患有单边与双边巨性MACS的患者中的发现.
- 确定区分单边和双边宏观模块MACS的因素.
主要方法:
- 对81名患有MACS的患者的回顾性分析.
- 对临床和实验室数据的评估,包括脱二三酸盐 (DHEA-S),糖化血红蛋白 (HbA1c) 和低密度脂蛋白 (LDL) 水平.
- 对上腺腺瘤和内区域的MRI信号强度指数 (SII) 的评估.
主要成果:
- 46名患者患有单边MACS,35名患有双边MACS.
- 在单边治疗组中观察到较低的DHEA-S水平 (p < .001).
- 在双边组中,2型糖尿病 (T2DM),HbA1c和LDL度的发病率较高 (p < .05).
- 上腺皮质激素 (ACTH),一夜间1毫克德甲抑制试验 (DST) 或SII之间没有显著差异.
- 后勤回归确定了DHEA-S,HbA1c和LDL作为区分单边和双边MACS的相关因素.
结论:
- 与单边腺瘤相比,双边宏节性MACS可能与较少抑制的DHEA-S水平有关.
- 在双边MACS患者中,T2DM和高胆固醇血症更为频繁.
- ACTH,夜间1mg DST和SII似乎没有帮助区分单边和双边的MACS.
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