COVID-19疫苗接种和焦虑症状的关联:一种以患者为中心的硬质皮肤干预网络 (SPIN) 队列纵向研究
Gabrielle Virgili-Gervais1, Richard S Henry2, Linda Kwakkenbos3
1Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.
Journal of psychosomatic research
|June 27, 2024
概括
在患有全身性硬化症 (SSc) 的人群中,COVID-19疫苗接种并没有显著改变焦虑症状. 虽然未接种疫苗的参与者后来表现出更高的焦虑,但疫苗接种本身似乎没有改变症状轨迹.
科学领域:
- 类风湿病学 类风湿病学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 在COVID-19大流行初期,系统性硬化症 (SSc) 患者的焦虑症状增加.
- 总体发现掩盖了疫苗接种对焦虑的个体水平影响.
- 这项研究旨在评估COVID-19疫苗接种对SSc患者焦虑的具体影响.
研究的目的:
- 调查COVID-19疫苗接种和系统性硬化症 (SSc) 患者焦虑症状水平之间的关联.
主要方法:
- 纵向数据采集自硬化皮肤病患者中心干预网络 (SPIN) COVID-19队列 (2020年4月至2022年8月) 的纵向数据.
- 每两周一次,然后每4周一次的焦虑症状评估使用PROMIS焦虑4a v1.0.0.
- 线性混合模型用于分析纵向趋势和疫苗接种相关性.
主要成果:
- 在517名参与者中,95%的人在2021年9月之前接种了疫苗.
- 在接种疫苗和未接种疫苗的个体中,焦虑症状轨迹在很大程度上是相似的.
- 从未接种疫苗的参与者在2022年8月之前报告了更高的焦虑症状,但接种疫苗并没有有意义地改变症状轨迹.
结论:
- 在大流行期间,COVID-19疫苗接种似乎没有影响SSc患者焦虑症状的变化.
- 接种疫苗后的行为变化 (例如,社会参与) 可能会稳定焦虑水平.
- 研究结果表明,仅接种疫苗可能不是这种脆弱人群中焦虑症状变化的主要驱动因素.
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