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常见的人类白细胞抗原与亚急性甲状腺炎和COVID-19的发展有关
Fatma Nur Korkmaz1, Asena Gökçay Canpolat1, Klara Dalva2
1Ankara University, Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism, Ankara, Türkiye.
Human immunology
|June 27, 2024
概括
人类白细胞抗原 (HLA) 基因组可能会影响对冠状病毒疾病-19 (COVID-19) 和随后的亚急性甲状腺炎 (SAT) 的敏感性. 特定的HLA类型与COVID-19和COVID-19后SAT的不同风险有关.
科学领域:
- 免疫遗传学 免疫遗传学
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
背景情况:
- 在冠状病毒疾病-19 (COVID-19) 之后报告了亚急性甲状腺炎 (SAT).
- 人类白细胞抗原 (HLA) 的等位基因已知与SAT相关.
- 了解对COVID-19和感染后SAT的遗传倾向至关重要.
研究的目的:
- 为了确定可能使个人易受COVID-19感染的特定HLA等位基因.
- 为了确定与COVID-19后亚急性甲状腺炎的发展相关的HLA基因.
- 研究HLA基因型与对COVID-19和SAT的易感性之间的关系.
主要方法:
- 一项回顾性研究涉及51名SAT患者和190名健康骨髓捐赠者.
- 使用下一代测序对HLA-A, -B, -C, -DRB1和 -DQB1进行基因定型.
- 根据SAT和COVID-19状态将参与者分为四组.
主要成果:
- 在COVID-19阳性个体中,HLA-DQB1*04:02的频率较低,这表明它对感染有保护作用.
- 特定的HLA等位基因 (HLA-B*35:01,HLA-B*35:03,HLA-DRB1*12:01,HLA-DRB1*14:01) 在SAT中表现出不同的频率. SAT(-) 没有COVID-19的个人.
- 在COVID-19阳性个体中,不同的HLA等位基因 (HLA-C*12:03,HLA-DQB1*06:04,HLA-DRB1*13:02,HLA-DRB1*13:03) 与SAT相关.
结论:
- 该研究确定了与对亚急性甲状腺炎 (SAT) 敏感性相关的特定人类白细胞抗原 (HLA) 基因.
- 鉴定到的HLA等位基因及其与SAT的关联似乎受到冠状病毒疾病-19 (COVID-19) 感染史的影响.
- 遗传因素,特别是HLA类型,在患COVID-19和随后的SAT的风险中发挥作用.
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