在COVID-19中塑造自身抗体生产的细胞通路和分子事件
Gregory J Tsay1, Moncef Zouali2
1Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; College of Medicine, China Medical University, Taichung, Taiwan.
Journal of autoimmunity
|June 27, 2024
概括
COVID-19可能会导致多器官并发症和自身抗体. 本综述探讨了COVID-19中自身抗体产生背后的机制,儿童多系统炎症综合征,以及COVID-19的后急性后果,将它们与免疫失调联系起来.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- COVID-19 (冠状病毒疾病2019) 呈现出多种多器官并发症,并与自身炎症性疾病和自身抗体有关.
- 在SARS-CoV-2感染中驱动自身抗体生产的精确机制仍然不完全理解.
研究的目的:
- 审查和批判性地讨论COVID-19中自身抗体生产的潜在机制.
- 探索自身抗体在儿童多系统炎症综合征 (MIS-C) 和COVID-19 (PASC) 后急性后果中的作用.
- 为自身抗体在COVID-19相关的后果中的致病作用提出模型.
主要方法:
- 文献综述和现有关于病毒感染和自身免疫性疾病中自身抗体产生研究的批判性讨论.
- 对包括基因组完整性,B细胞耐受性,病毒超抗原和B细胞激活在内的拟议机制的分析.
- 在COVID-19中对自身抗体病原发生的概念模型的开发.
主要成果:
- 提出了几种机制,有助于在COVID-19中产生自身抗体,包括基因组损伤,B细胞自我耐受性丧失,病毒超抗原活性和额外毛囊B细胞激活.
- 自体抗体与促进COVID-19和相关疾病中的炎症级联,血栓塞栓事件和内皮/血管功能障碍有关.
- 介绍了模型,以解释自身抗体对多系统炎症和长期后果的致病性贡献.
结论:
- 在COVID-19中,自身抗体的产生是一个复杂的现象,由多个免疫失调路径驱动.
- 了解这些机制对于开发针对COVID-19并发症,MIS-C和PASC的向疗法至关重要.
- 需要进一步的研究,以充分阐明自身抗体在SARS-CoV-2感染的发病和长期影响中的作用.
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