细菌细菌fmbj通过增强SIRT1/PGC1α通路来改善肉中脂聚糖诱导的肠道功能障碍
Luyi Jiang1, Kaiwen Bai2, Tian Wang3
1College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310023, China; Institute of Dairy Science, Ministry of Education Key Laboratory of Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou, 310023, China.
Poultry science
|June 27, 2024
概括
饮食补充Bacillus subtilis fmbj (BS) 显示了保护 brojlers免受脂多糖 (LPS) 诱导的肠道功能障碍的潜力. BS可以通过增强抗氧化能力和细胞功能来改善肠道健康.
科学领域:
- 动物科学动物科学
- 肠道健康 肠道健康
- 微生物学 微生物学
背景情况:
- 脂多糖 (LPS) 诱导肉的急性肠道功能障碍,影响肠道形态和功能.
- 氧化应激和基因表达的改变是LPS诱导肠炎的关键特征.
研究的目的:
- 为了研究饮食中的Bacillus subtilis fmbj (BS) 对肉LPS诱导的肠功能障碍的保护作用.
- 评估BS对肠道形态,氧化应激和相关基因/蛋白质表达的影响.
主要方法:
- 一百八十只肉被分为控制,LPS挑战和LPS挑战的BS补充组.
- 用LPS进行内注射,以诱导急性肠道功能障碍.
- 评估了小肠形态,抗氧化能力,氧化损伤和基因/蛋白质表达.
主要成果:
- LPS挑战显著破坏了小肠道形态,抗氧化能力和诱导氧化损伤.
- LPS改变了参与抗氧化防御,细胞粘附和线粒体功能中的基因和蛋白质的表达.
- 补充BS往往会改善这些负面影响,改善肠道健康指标.
结论:
- 补充Bacillus subtilis fmbj (BS) 可能会保护肉免受LPS引起的急性肠功能障碍.
- BS有可能增强SIRT1/PGC1α通路,改善抗氧化能力和肠道屏障功能.
- 作为家禽行业有益的料添加剂,BS显示出前景.
相关概念视频
01:19Formation of Lipopolysaccharides
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01:28Regulation of Bacterial Virulence
Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...