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探索神经成像协会成绩在成年期的ADHD和中年轨迹

Cibele Edom Bandeira¹, Eugenio Horacio Grevet², Eduardo Schneider Vitola¹

¹ADHD Outpatient Program, Clinical Research Center, Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Physiological Genomics of Mental Health (PhysioGen Lab), Instituto de Ciencias Biomedicas da Universidade de São Paulo, São Paulo, Brazil.

Journal of psychiatric research

|June 27, 2024

概括

与对照人群相比,注意力缺陷/多动障碍 (ADHD) 的成年人中皮层表面积的神经成像协会评分 (NAS) 较高. 然而,NAS与成人时的ADHD症状严重程度或临床过程没有相关性.

科学领域:

神经成像是一种神经成像.
精神病学是一个精神病学.
神经发育障碍神经发育障碍

背景情况:

注意缺陷/多动障碍 (ADHD) 是一种神经发育障碍,在儿童中存在已知的大脑差异.
以前的研究并没有在ADHD成年人中始终确定大脑差异.
对区域大脑差异的综合分析可能会增强检测成人多动症相关影响的统计能力.

研究的目的:

为了研究神经成像协会分数 (NAS) 和成人多动症之间的关联.
探索NAS和中年ADHD的临床轨迹之间的关系.
通过使用NAS来确定ADHD成年人是否可以检测到结构性大脑差异.

主要方法:

收集了121名ADHD成年人和82名对照者的临床和神经成像数据.
在基线,诊断后7年和13年评估ADHD病例,以对临床轨迹进行分类 (稳定与不稳定).
基于对皮质厚度,皮质表面积和皮质下体积的元分析,从从基线后13年获得的神经成像数据中计算NAS.

主要成果:

与对照人群相比,ADHD成年人的皮质表面积神经影像协会得分 (NAS) 显著高于ADHD成年人.
在NAS和ADHD症状数量之间没有发现显著的关联.
在NAS和中年ADHD的临床轨迹 (稳定与不稳定) 之间没有观察到任何关联.

结论:

结构性大脑差异,特别是皮质表面积,与成年期ADHD的诊断状态有关.
这些发现表明成年人对ADHD的潜在易感性影响,但不一定是症状严重程度或长期临床过程.
评估整体神经成像效应可能有利于研究成年ADHD.

关键词:

更多关于 ADHD ADHD 的文章大人的成年人.中年临床轨迹中年临床轨迹神经成像协会得分神经成像协会得分

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