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相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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DNA-only Transposons02:57

DNA-only Transposons

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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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相关实验视频

Updated: Jun 22, 2025

Identification of Sleeping Beauty Transposon Insertions in Solid Tumors using Linker-mediated PCR
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针对癌症中的可移植元素:发展和机遇

Zi-Yu Wang1, Li-Ping Ge1, Yang Ouyang1

  • 1Department of Breast Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Biochimica et biophysica acta. Reviews on cancer
|June 27, 2024
PubMed
概括

可移植元素 (TE) 在癌症中至关重要. 针对TEs的新疗法,如逆转录酶抑制剂,在与当前方法相结合时,有望改善癌症治疗.

关键词:
癌症的进展情况.癌症治疗治疗 癌症治疗技术的进步,技术的进步.可转移的要素是可以转移的.瘤免疫系统的免疫力

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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

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Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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科学领域:

  • 基因组学就是基因组学.
  • 在瘤学瘤学.
  • 分子生物学分子生物学

背景情况:

  • 可移植元素 (TE) 占人类基因组的近50%.
  • 在历史上被视为"基因组垃圾",TEs现在被认为在生物过程中发挥着重要作用,包括癌症的发展.

研究的目的:

  • 审查最近在检测可转移元素 (TE) 的进展.
  • 探索TEs在瘤发生和免疫调节中的多方面的作用.
  • 讨论新兴的诊断和治疗策略,以瘤学为目标.

主要方法:

  • 综合长读序列,计算分析,单细胞序列,蛋白质组学和CRISPR-Cas9技术的当代研究.
  • 对癌症中改变的TE模式 (LINE-1,Alus,LTRs) 的分析.
  • 检查TE衍生的核酸和瘤抗原在癌症免疫中的作用.

主要成果:

  • TE 调节障碍与癌症的发展有关.
  • 改变TE活性会影响瘤原生和瘤抑制机制.
  • TE衍生分子在弥合先天性和适应性抗瘤免疫反应中发挥着关键作用.

结论:

  • 可移植的元素是癌症进展和免疫力的关键参与者.
  • 针对TE的疗法,包括逆转录酶抑制剂和表观遗传调节剂,提供了新的治疗途径.
  • 将以 TE 为重点的策略与现有的癌症疗法结合起来,可能会提高治疗效率.