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高强度间歇训练和中强度持续训练可能会通过肠道肠道微生物组成及其代谢物LPS通过肠-大脑轴的调节来影响认知功能

Mei Peng¹, Ruihan Zou¹, Sisi Yao¹

¹Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Hunan Normal University, Changsha 410012, China.

|June 27, 2024

概括

高强度间歇训练 (HIIT) 可能通过增加肠道衍生的脂多糖 (LPS) 和大脑炎症,对认知功能产生负面影响. 中等强度持续训练 (MICT) 可能通过肠-大脑轴为认知健康提供更安全的替代方案.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
运动生理学运动生理学

背景情况:

肠-大脑轴描述了肠和中枢神经系统之间的双向通信.
肠道微生物群和脂多糖 (LPS) 是这个轴的关键调解者.
运动会影响肠道微生物群的组成和LPS的产生.

研究的目的:

研究高强度间歇训练 (HIIT) 和中等强度持续训练 (MICT) 对小鼠认知功能的影响.
探索肠-大脑轴,肠道微生物群和LPS在调解这些影响中的作用.
识别与不同强度的运动相关的潜在风险对认知健康的影响.

主要方法:

雄性C57BL/6J小鼠被分配到久坐,HIIT或MICT组12周.
评估了认知功能,大脑炎症标志物和肠道微生物群组成.
这些技术包括RNA测序,戈尔吉染色,16SrDNA测序和ELISA.

主要成果:

通过改变肠道微生物群和LPS水平,HIIT和MICT都通过肠-大脑轴调节认知功能.
HIIT可能会引发"肠道泄漏",导致血液和大脑LPS的增加.
这种LPS的增加激活了M1微质,减少了树突脊柱密度和认知功能受损.

结论:

肠道微生物群变化与认知功能变化之间存在联系.
通过减少树突脊柱密度,HIIT对认知功能构成潜在的风险.
通过肠-大脑轴,MICT可能代表一种更安全的炼方式来维持认知健康.

关键词:

认知功能认知功能我们的肠道微生物群.肠-大脑轴肠-大脑轴高强度间歇训练高强度间歇训练脂聚糖类糖化物脂聚糖类糖化物适度强度的持续训练适度强度的持续训练

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