戈尔吉装置针对癌症的向疗法:我们还在那里吗?
Zheng Yang Lee1, Wen Hwei Lee1, Jing Sheng Lim1
1School of Pharmacy, Faculty of Health and Medical Sciences, Taylor's University, 47500 Subang Jaya, Selangor, Malaysia.
Life sciences
|June 27, 2024
概括
癌细胞利用戈尔吉器官缺陷进行生长和扩散. 本综述详细介绍了癌症中的异常戈尔吉基因和新兴的针对戈尔吉基因的药物,强调了进一步开发治疗患者的必要性.
科学领域:
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
- 分子医学是分子医学.
背景情况:
- 戈尔吉装置中的膜运输对于蛋白质和脂质运输至关重要.
- 失调的戈尔基贩运与癌症进展有关,有助于诸如扩散和转移等过程.
- 目前的治疗策略缺乏针对癌症的特定药物.
研究的目的:
- 划分异常的戈尔吉基因和参与致癌的蛋白质.
- 检查基因变异对戈尔吉功能的影响,包括贩运,糖化和pH值.
- 为癌症治疗临床试验中的戈尔吉装置向抑制剂提供最新信息.
主要方法:
- 关于戈尔吉仪器和癌症的综合文献综述.
- 对与戈尔吉异常相关的分子信号通路的分析.
- 对戈尔吉向抑制剂的临床前和临床数据的调查.
主要成果:
- 确定了特定的异常戈尔吉基因和蛋白质,这些基因和蛋白质有助于癌症的发展.
- 详细介绍了高尔基变异对细胞过程的功能后果.
- 目前正在开发的有前途的高尔基装置向抑制剂. 目前正在开发.
结论:
- 异常的戈尔吉贩运是癌细胞利用的一个关键特征.
- 准戈尔吉装置是一个有希望的,但尚未开发的治疗途径.
- 进一步的研究和开发对于将高尔基向抑制剂转化为有效的癌症治疗方法至关重要.
更多相关视频
12:55Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
21.4K
09:37Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
1.8K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:09Golgi Apparatus
14.4K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
14.4K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
510
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
510
01:12Golgi Matrix Proteins
2.0K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
2.0K
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K