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阐明了对质子感应GPR68受体的激活机制

Christos Matsingos1, Lesley A Howell1, Peter J McCormick2

  • 1Department of Chemistry, School of Physical and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.

Journal of molecular biology
|June 27, 2024
PubMed
概括

一个质子感应受体GPR68在质子化时经历了部分激活. 模拟显示了关键的残留物相互作用和一种新的疏水性锁定,稳定了其非活性状态.

关键词:
分子动力学分子动力学微型开关 微型开关pK(a) 调制方式具有质子感应的GPCRs.在位点导向的突变发生.

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