患有初级开角玻璃眼患者水性幽默中的VEGF-A水平升高
Georgios S Dimtsas1, Alexandra Ieronymaki2, Klio I Chatzistefanou2
1First Department of Ophthalmology, National and Kapodistrian University of Athens, "G. Gennimatas" General Hospital, Athens, Greece; gdimtsas@med.uoa.gr.
In vivo (Athens, Greece)
|June 27, 2024
概括
血管内皮生长因子-A (VEGF-A) 在患有初级开角玻璃眼 (POAG) 患者的水性幽默中升高. 升高的VEGF-A水平显示POAG的预后能力,表明潜在的诊断价值.
科学领域:
- 眼科医生 眼科 眼科
- 生物化学 生化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 主要开角青光眼 (POAG) 是全球不可逆转失明的主要原因.
- 了解POAG背后的分子机制对于开发有效的诊断和治疗策略至关重要.
研究的目的:
- 为了比较患有POAG的患者的血管内皮生长因子-A (VEGF-A) 水溶液水平与非白内障对照.
- 研究VEGF-A作为POAG.的预后生物标志物的潜力.
主要方法:
- 这是一项涉及76名参与者的观察性横截面研究 (39名POAG,36名对照).
- 在手术期间采集的水性幽默样品.
- 使用多重珠型免疫试验量化VEGF-A水平.
主要成果:
- 与对照组 (119.02±49.09 pg/ml; p=0.011) 相比,在POAG组 (166.37±110.04 pg/ml) 观察到显著增加的VEGF-A水平.
- 接收器操作特征 (ROC) 分析表明POAG具有显著的预后能力 (AUC=0.67;p=0.006).
- 在调整年龄和性别后,VEGF-A水平>148.5 pg/ml与POAG的可能性增加了近10倍.
结论:
- 在POAG患者的水性幽默中,VEGF-A明显升高.
- VEGF-A具有作为初级开角青光眼的预后生物标志物的潜力.
相关概念视频
01:27Open Angle Glaucoma: Treatment
427
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
427
01:25Glaucoma: Overview
538
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
538
01:28Angle Closure Glaucoma: Treatment
471
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
471
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K