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Updated: Jun 22, 2025

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用于化疗诱导的外围神经病变的 gabapentinoids:系统性审查和元分析

Tsung Wei Chang¹, Fu-Yu Yang¹, Yu-Chang Liu^2,3

¹Pharmacy, Yuanlin Christian Hospital, Changhua, Taiwan.

BMJ supportive & palliative care

|June 27, 2024

概括

gabapentinoids 没有显著地预防化疗诱导的周围神经病变 (CIPN). 虽然一些研究表明对治疗现有的CIPN有潜在的治疗效果,但结果不一致,表明Gabapentinoid在CIPN管理中的使用证据有限.

科学领域:

在瘤学瘤学.
神经学神经学
药理学药理学是指药理学的学科.

背景情况:

化疗诱导的周围神经病变 (CIPN) 显著影响患者的生活质量和治疗结果.
gabapentinoids (gabapentin,pregabalin) 通常用于CIPN,但它们的有效性和安全性需要进一步调查.
这项研究批判性地评估了现有的随机对照试验数据,以澄清 gabapentinoids 在 CIPN 中的作用.

研究的目的:

系统地审查和元分析随机对照试验 (RCT),评估 gabapentinoids 预防和治疗 CIPN 的有效性和安全性.
提供基于证据的洞察力,了解 gabapentinoids 对治疗化疗相关神经损伤的临床实用性.

主要方法:

在PubMed,Embase和Cochrane CENTRAL进行了全面的文献搜索,截至2022年8月29日.
使用RevMan V.5.4和R中的Metafor包进行了元分析,重点关注疼痛得分,生活质量和不良事件.
由于显著的异质性,对治疗环境进行元分析是不可行的.

主要成果:

在预防设置中,与安慰剂相比,普雷加巴林在平均疼痛或生活质量方面没有显著改善.
在使用普雷加巴林时,观察到减少最严重疼痛的趋势,尽管在统计学上不显著 (p=0.06).
对于CIPN治疗,研究产生了不一致的结果,排除了最终的元分析.

结论:

目前的证据表明, gabapentinoids 在预防CIPN方面提供了有限的益处.
由于研究结果不一致, gabapentinoids 在治疗已建立的 CIPN 的疗效仍然不确定.
进一步进行高质量的研究是必不可少的,以确定GABAPENTINOIDS对CIPN的最终益处和最佳使用.

关键词:

癌症癌症癌症癌症医院护理医院护理

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