评估Lenabasum的滥用潜力,这是一个选择性大麻素受体2激动体
Rachel Luba1, Gabriela Madera2, Rebecca Schusterman2
1Department of Psychiatry, Columbia University Irving Medical Center, New York, New York (R.L., S.D.C.); Division on Substance Use Disorders, New York State Psychiatric Institute and Columbia University, New York, New York (R.L., G.M., R.S., S.D.C.); and Corbus Pharmaceuticals, Norwood, Massachusetts (A.K., I.H.) Rachel.Luba@nyspi.columbia.edu.
作为CB2受体激动剂的Lenabasum被评估为娱乐大麻使用者的滥用潜力. 虽然治疗剂量 (20毫克) 没有增加药物嗜好,但较高剂量确实增加了,这表明滥用潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 药物滥用研究 药物滥用研究
背景情况:
- 内分类药物通过激活大麻素受体 (CB1和CB2) 来调节中枢神经系统 (CNS).
- CB1和CB2激动剂具有抗炎性质,表明对炎症性疾病的治疗潜力.
- 在临床应用之前,评估新型大麻素受体激动剂的滥用潜力至关重要.
研究的目的:
- 为了评估lenabasum的滥用潜力,一个选择性的CB2受体激动剂.
- 为了比较lenabasum与安慰剂和nabilone在有娱乐大麻使用史的人群中的主观影响.
主要方法:
- 这是一项双盲,安慰剂控制的研究,涉及56名具有娱乐大麻使用史的参与者.
- 服用了三个剂量的莱纳巴 (20,60,120毫克),安慰剂和纳比隆 (3,6毫克).
- 主要终点:喜欢药物的视觉模拟尺度 (VAS);次要终点:其他VAS,药理动力学和不良事件.
主要成果:
- 莱纳巴苏姆是安全的,并且在所有剂量中都能耐受.
- 与安慰剂相比,20mg的lenabasum剂量没有增加药物喜欢评级.
- 较高剂量 (60,120毫克) 的lenabasum显示剂量依赖于药物喜欢的增加,虽然不如nabilone.
- 纳比龙 (3,6毫克) 产生了最高的药物喜欢评分.
结论:
- 在目标治疗剂量 (20 毫克) 中,lenabasum 似乎在这个人群中没有显著的滥用潜力.
- 莱纳巴的超治疗剂量具有滥用潜力,因此在临床环境中需要谨慎使用.
- 莱纳巴苏姆的安全性和耐受性概况支持进一步开发潜在的治疗指示,并仔细监测滥用情况.
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